M., Chopinaud D., Labbé C., Creveuil M., Marc H., Bénateau B., Mourgeon E., Chopinaud A., Veyssière A., Dompmartin Supplementary Material for: Autologous Adipose Tissue Graft to Treat Hypertensive Leg Ulcer: A Pilot Study <p><b><i>Background:</i></b> Adipose tissue is an abundant source of mesenchymal stem cells, called adipose-derived stem cells, which have anti-inflammatory and trophic effects to enhance overall tissue repair. <b><i>Objective:</i></b> To determine the healing effects of autologous adipose tissue graft on hypertensive leg ulcers. <b><i>Methods:</i></b> Prospective pilot study in 1 French dermatology department. Ten patients with a hypertensive leg ulcer were enrolled from April 2013 to June 2015. The primary end point was the wound closure rate at each follow-up visit. The secondary end points were wound characteristics, pain assessment and adverse events. <b><i>Results:</i></b> One patient, the only smoker, was lost to follow-up at month 5 (M5). For the 9 non-smokers, wound surfaces constantly and significantly decreased: the median wound closure rate was 73.2% at M3 and 93.1% at M6, <i>p</i> < 0.001. The median wound closure rate of the 10 patients was 63.2% at M3, <i>p</i> < 0.001. Percentages of fibrin and necrosis decreased, granulation tissue increased significantly. Pain rapidly and significantly decreased. No recurrence or adverse event was observed. <b><i>Conclusion:</i></b> Our data suggest that autologous adipose tissue grafting induces pain relief and promotes wound healing with a good skin quality. Large prospective controlled randomized studies are required to confirm these results.</p> Wound healing;Hypertensive leg ulcer;Autologous adipose tissue graft;Adipose tissue;Adipose-derived stem cells;Tissue regeneration 2017-07-26
    https://karger.figshare.com/articles/journal_contribution/Supplementary_Material_for_Autologous_Adipose_Tissue_Graft_to_Treat_Hypertensive_Leg_Ulcer_A_Pilot_Study/5245264
10.6084/m9.figshare.5245264.v1