TY - DATA T1 - Supplementary Material for: Autologous Adipose Tissue Graft to Treat Hypertensive Leg Ulcer: A Pilot Study PY - 2017/07/26 AU - Chopinaud M. AU - Labbé D. AU - Creveuil C. AU - Marc M. AU - Bénateau H. AU - Mourgeon B. AU - Chopinaud E. AU - Veyssière A. AU - Dompmartin A. UR - https://karger.figshare.com/articles/journal_contribution/Supplementary_Material_for_Autologous_Adipose_Tissue_Graft_to_Treat_Hypertensive_Leg_Ulcer_A_Pilot_Study/5245264 DO - 10.6084/m9.figshare.5245264.v1 L4 - https://ndownloader.figshare.com/files/8965360 KW - Wound healing KW - Hypertensive leg ulcer KW - Autologous adipose tissue graft KW - Adipose tissue KW - Adipose-derived stem cells KW - Tissue regeneration N2 - Background: Adipose tissue is an abundant source of mesenchymal stem cells, called adipose-derived stem cells, which have anti-inflammatory and trophic effects to enhance overall tissue repair. Objective: To determine the healing effects of autologous adipose tissue graft on hypertensive leg ulcers. Methods: Prospective pilot study in 1 French dermatology department. Ten patients with a hypertensive leg ulcer were enrolled from April 2013 to June 2015. The primary end point was the wound closure rate at each follow-up visit. The secondary end points were wound characteristics, pain assessment and adverse events. Results: One patient, the only smoker, was lost to follow-up at month 5 (M5). For the 9 non-smokers, wound surfaces constantly and significantly decreased: the median wound closure rate was 73.2% at M3 and 93.1% at M6, p < 0.001. The median wound closure rate of the 10 patients was 63.2% at M3, p < 0.001. Percentages of fibrin and necrosis decreased, granulation tissue increased significantly. Pain rapidly and significantly decreased. No recurrence or adverse event was observed. Conclusion: Our data suggest that autologous adipose tissue grafting induces pain relief and promotes wound healing with a good skin quality. Large prospective controlled randomized studies are required to confirm these results. ER -