%0 Generic %A Y., Xia %A Q., Chen %A Z., Zhong %A C., Xu %A C., Wu %A B., Liu %A Y., Chen %D 2017 %T Erratum: Down-Regulation of MiR-30c Promotes the Invasion of Non-Small Cell Lung Cancer by Targeting MTA1 %U https://karger.figshare.com/articles/dataset/Erratum_Down-Regulation_of_MiR-30c_Promotes_the_Invasion_of_Non-Small_Cell_Lung_Cancer_by_Targeting_MTA1/5241565 %R 10.6084/m9.figshare.5241565.v1 %2 https://ndownloader.figshare.com/files/8956234 %K MicroRNA-30c %K MTA1 %K Invasion %K NSCLC %X Background: The connection between microRNA expression and lung cancer development has been identified in recent literature. However, the mechanism of microRNA has been poorly elucidated in non-small-cell lung cancer (NSCLC). Methods and Results: Comparing with adjacent tissues (n=75), miR-30c has a lower expression in lung cancer specimens (n=75). The knockdown of miR-30c enhanced the invasion of A549 cells; meanwhile, the overexpression of miR-30c could reverse the effect of the knockdown of miR-30c in vitro. A luciferase assay revealed that miR-30c was directly bound to the 3‘-untranslated regions (3‘-UTR) of MTA1. QRT-PCR and western blot shows MTA1 was up-regulated in mRNA and protein levels. The effect taken on the invasion of NSCLC by overexpression of MTA1 works the same as down-regulated miR-30c. Conclusion: miR-30c may play a pivotal role in controlling lung cancer invasion through regulating MTA1in NSCLC. %I Karger Publishers