%0 Generic
%A Y., Xia
%A Q., Chen
%A Z., Zhong
%A C., Xu
%A C., Wu
%A B., Liu
%A Y., Chen
%D 2017
%T Erratum: Down-Regulation of MiR-30c Promotes the Invasion of Non-Small Cell Lung Cancer by Targeting MTA1
%U https://karger.figshare.com/articles/dataset/Erratum_Down-Regulation_of_MiR-30c_Promotes_the_Invasion_of_Non-Small_Cell_Lung_Cancer_by_Targeting_MTA1/5241565
%R 10.6084/m9.figshare.5241565.v1
%2 https://ndownloader.figshare.com/files/8956234
%K MicroRNA-30c
%K MTA1
%K Invasion
%K NSCLC
%X Background: The connection between microRNA expression and lung cancer development has been identified in recent literature. However, the mechanism of microRNA has been poorly elucidated in non-small-cell lung cancer (NSCLC). Methods and Results: Comparing with adjacent tissues (n=75), miR-30c has a lower expression in lung cancer specimens (n=75). The knockdown of miR-30c enhanced the invasion of A549 cells; meanwhile, the overexpression of miR-30c could reverse the effect of the knockdown of miR-30c in vitro. A luciferase assay revealed that miR-30c was directly bound to the 3‘-untranslated regions (3‘-UTR) of MTA1. QRT-PCR and western blot shows MTA1 was up-regulated in mRNA and protein levels. The effect taken on the invasion of NSCLC by overexpression of MTA1 works the same as down-regulated miR-30c. Conclusion: miR-30c may play a pivotal role in controlling lung cancer invasion through regulating MTA1in NSCLC.
%I Karger Publishers