TY - DATA T1 - Erratum: Vasculopathy Related to Manic/Hypomanic Symptom Burden and First-Generation Antipsychotics in a Sub-Sample from the Collaborative Depression Study PY - 2017/07/25 AU - Fiedorowicz J.G. AU - Coryell W.H. AU - Rice J.P. AU - Warren L.L. AU - Haynes W.G. UR - https://karger.figshare.com/articles/dataset/Erratum_Vasculopathy_Related_to_Manic_Hypomanic_Symptom_Burden_and_First-Generation_Antipsychotics_in_a_Sub-Sample_from_the_Collaborative_Depression_Study/5241370 DO - 10.6084/m9.figshare.5241370.v1 L4 - https://ndownloader.figshare.com/files/8955991 KW - Adult KW - Antipsychotics KW - Major depression KW - Bipolar disorder KW - Cardiovascular mortality KW - Mania N2 - Background: Mood disorders substantially increase the risk of cardiovascular disease, though the mechanisms are unclear. We assessed for a dose-dependent relationship between course of illness or treatment with vasculopathy in a well-characterized cohort. Methods: Participants with mood disorders were recruited for the National Institute of Mental Health Collaborative Depression Study (CDS) and followed prospectively. A cross-sectional metabolic and vascular function evaluation was performed on a sub-sample near completion after a mean follow-up of 27 years. Results: A total of 35 participants from the University of Iowa (33) and Washington University (2) sites of the CDS consented to a metabolic and vascular function assessment at the Iowa site. In multivariate linear regression, controlling for age, gender, and smoking, manic/hypomanic, but not depressive, symptom burden was associated with lower flow-mediated dilation. Cumulative exposure to antipsychotics and mood stabilizers was associated with elevated augmentation pressure and mean aortic systolic blood pressure. This appeared specifically related to first-generation antipsychotic exposure and mediated by increases in brachial systolic pressure. Although second-generation antipsychotics were associated with dyslipidemia and insulin resistance, they were not associated with vasculopathy. Conclusions: These results provide evidence that chronicity of mood symptoms contribute to vasculopathy in a dose-dependent fashion. Patients with more manic/hypomanic symptoms had poorer endothelial function. First-generation antipsychotic exposure was associated with arterial stiffness, evidenced by higher augmentation pressure, perhaps secondary to elevated blood pressure. Vascular phenotyping methods may provide a promising means of elucidating the mechanisms linking mood disorders to vascular disease. ER -