Erratum: RETRACTION: Intraoperative Touch Imprint Cytological Analysis of Sentinel Lymph Nodes for the Presence of Metastases in Breast Cancer
Tamiolakis D.
Papadopoulos N.
Venizelos J.
Lambropoulou M.
Romanidis C.
Petrakis G.
Limberis V.
Galazios G.
Koutsougeras G.
Simopoulos C.
10.6084/m9.figshare.5241064.v1
https://karger.figshare.com/articles/dataset/Erratum_RETRACTION_Intraoperative_Touch_Imprint_Cytological_Analysis_of_Sentinel_Lymph_Nodes_for_the_Presence_of_Metastases_in_Breast_Cancer/5241064
Background: Imprint cytology may provide a fast and accurate
method for intraoperative screening of sentinel lymph nodes,
so a decision can be made regarding whether to perform axillary
clearance during primary surgery. If the findings are negative,
in many cases axillary dissection can be omitted. Patients
and Methods: 128 sentinel nodes from a cohort of 87 patients
that had been identified using technetium-99m nanocolloid as a
radioactive tracer and Patent blue dye were disected for rapid
Diff-Quick stained touch preparations. Intraoperative evaluation
of sentinel node status by imprint cytology was correlated with
histopathological results of permanent sections. Tumor-negative
nodes in routine paraffin sections were further investigated
with the employment of an anti-cytokeratin antibody. Results:
36 of all sentinel nodes harbored metastases in the paraffin sections,
of which 32 were identified by imprint cytology (sensitivity
88.8%). 3 sentinel nodes were positive by imprint cytology
and negative by histopathology of the paraffin sections. Comparison
of the results of the touch preparations with the final
histopathology (hematoxylin-eosin and anticytokeratin antibody
stains) demonstrated a sensitivity of 83.3% and a negative
predictive value of 92.5%. The specificity and positive predictive
value were 100% each. Conclusions: Touch imprint cytology is
potentially useful for intraoperative evaluation of sentinel
lymph nodes in breast cancer patients.
2017-07-25 13:21:36
Medicine