Multifunctional
Nanoplatform Based on Black Phosphorus Quantum Dots for Bioimaging
and Photodynamic/Photothermal Synergistic Cancer Therapy
Yi Li
Zhiming Liu
Yuqing Hou
Guangcun Yang
Xixi Fei
Henan Zhao
Yanxian Guo
Chengkang Su
Zhen Wang
Huiqing Zhong
Zhengfei Zhuang
Zhouyi Guo
10.1021/acsami.7b05824.s001
https://acs.figshare.com/articles/journal_contribution/Multifunctional_Nanoplatform_Based_on_Black_Phosphorus_Quantum_Dots_for_Bioimaging_and_Photodynamic_Photothermal_Synergistic_Cancer_Therapy/5226349
A multifunctional
nanoplatform based on black phosphorus quantum dots (BPQDs) was developed
for cancer bioimaging and combined photothermal therapy (PTT) and
photodynamic therapy (PDT). BPQDs were functionalized with PEG chains
to achieve improved biocompatibility and physiological stability.
The as-prepared nanoparticles exhibite prominent near-infrared (NIR)
photothermal and red-light-triggered photodynamic properties. The
combined therapeutic application of PEGylated BPQDs were then performed
in vitro and in vivo. The results demonstrate that the combined phototherapy
significantly promote the therapeutic efficacy of cancer treatment
in comparison with PTT or PDT alone. BPQDs could also serve as the
loading platform for fluorescent molecules, allowing reliable imaging
of cancer cells. In addition, the low cytotoxicity and negligible
side effects to main organs were observed in toxicity experiments.
The theranostic characteristics of PEGylated BPQDs provide an uplifting
potential for the future clinical applications.
2017-07-03 00:00:00
PTT
application
PEGylated BPQDs
red-light-triggered photodynamic properties
as-prepared nanoparticles exhibite
phosphorus quantum dots
PDT
photothermal
NIR
Black Phosphorus Quantum Dots
therapy