TY - DATA T1 - Moderate anemia at diagnosis is an independent prognostic marker of the EUTOS, Sokal, and Hasford scores for survival and treatment response in chronic-phase, chronic myeloid leukemia patients with frontline imatinib PY - 2017/08/11 AU - Po-Shen Ko AU - Yuan-Bin Yu AU - Yao-Chung Liu AU - Yi-Tsui Wu AU - Man-Hsin Hung AU - Jyh-Pyng Gau AU - Chia-Jen Liu AU - Liang-Tsai Hsiao AU - Po-Min Chen AU - Tzeon-Jye Chiou AU - Chun-Yu Liu AU - Jin-Hwang Liu UR - https://tandf.figshare.com/articles/dataset/Moderate_anemia_at_diagnosis_is_an_independent_prognostic_marker_of_the_EUTOS_Sokal_and_Hasford_scores_for_survival_and_treatment_response_in_chronic-phase_chronic_myeloid_leukemia_patients_with_frontline_imatinib/5217202 DO - 10.6084/m9.figshare.5217202.v2 L4 - https://ndownloader.figshare.com/files/8908585 L4 - https://ndownloader.figshare.com/files/8908582 L4 - https://ndownloader.figshare.com/files/8908579 L4 - https://ndownloader.figshare.com/files/8908576 KW - Chronic myeloid leukemia KW - anemia KW - scoring systems KW - prognosis N2 - Objectives: This study aimed to examine the prognostic value of anemia for the diagnosis of chronic myeloid leukemia in the chronic phase (CML-CP) receiving imatinib. Methods: One hundred and fifty-four CML-CP patients were enrolled. The influences of moderate anemia with hemoglobin (Hb) < 10 g/dl, four scoring systems, and the early molecular response at 3 months (BCR-ABL ≤10%; 3M-EMR) on the achievement of a deep molecular response (DMR, MR4.5), progression-free survival (PFS), event-free survival (EFS), and overall survival (OS) were compared. Results: Moderate anemia was identified in 44 (28.6%) patients. These patients had more aggressive baseline features and higher risks, as assessed by scoring systems, and less favorable treatment responses vs those without anemia, including 3M-EMR (50.0% vs 69.1%), a complete cytogenetic response at 6 months (20.5% vs 50.9%), and a major molecular response at 12 months (22.5% vs 45.2%), with a median follow-up of 54.0 months. Furthermore, an Hb of 10 g/dl better distinguished DMR, EFS, PFS, and OS than the EUTOS, Sokal, and Hasford scores, and better predicted the responses and survivals in combination with 3M-EMR than 3M-EMR alone. Conclusions: This finding highlights the significance of anemia in CML-CP, and suggests that patients with anemia at diagnosis should be carefully monitored and might benefit from more potent TKIs if not achieving 3M-EMR. ER -