TY - DATA T1 - CH872 and CA272 antileishmanial activity against intracellular L. major amastigotes. PY - 2010/05/04 AU - Jair L. Siqueira-Neto AU - Ok-Ryul Song AU - Hyunrim Oh AU - Jeong-Hun Sohn AU - Gyongseon Yang AU - Jiyoun Nam AU - Jiyeon Jang AU - Jonathan Cechetto AU - Chang Bok Lee AU - Seunghyun Moon AU - Auguste Genovesio AU - Eric Chatelain AU - Thierry Christophe AU - Lucio H. Freitas-Junior UR - https://plos.figshare.com/articles/figure/_CH872_and_CA272_antileishmanial_activity_against_intracellular_L_major_amastigotes_/521593 DO - 10.1371/journal.pntd.0000675.g003 L4 - https://ndownloader.figshare.com/files/851146 KW - ca272 KW - antileishmanial KW - intracellular N2 - A) Infected THP-1 cells in the presence of 1% DMSO as a negative control (left) and EC100 obtained with 10 µM of amphotericin B as a positive control (right). B) Structures of CH872 (left) and CA272 (right). C) Infected THP-1 cells in the presence of 1 nM of CH872 (left) and 1 nM of CA272 (right) as non-active concentrations of the compounds and D) in the presence of 0.7 µM of CH872 (left) and 10 µM of CA272 (right) as effective concentrations from the dose-response curves. E) Dose-response curves of the compounds CH872 and CA272 plotting the infection ratio (continuous lines) and relative number of parasites compared to the DMSO control (dashed lines). ER -