CH872 and CA272 antileishmanial activity against intracellular <i>L. major</i> amastigotes. Siqueira-NetoJair L. SongOk-Ryul OhHyunrim SohnJeong-Hun YangGyongseon NamJiyoun JangJiyeon CechettoJonathan Bok LeeChang MoonSeunghyun GenovesioAuguste ChatelainEric ChristopheThierry H. Freitas-JuniorLucio 2010 <p><b>A</b>) Infected THP-1 cells in the presence of 1% DMSO as a negative control (left) and EC<sub>100</sub> obtained with 10 µM of amphotericin B as a positive control (right). <b>B</b>) Structures of CH872 (left) and CA272 (right). <b>C</b>) Infected THP-1 cells in the presence of 1 nM of CH872 (left) and 1 nM of CA272 (right) as non-active concentrations of the compounds and <b>D</b>) in the presence of 0.7 µM of CH872 (left) and 10 µM of CA272 (right) as effective concentrations from the dose-response curves. <b>E</b>) Dose-response curves of the compounds CH872 and CA272 plotting the infection ratio (continuous lines) and relative number of parasites compared to the DMSO control (dashed lines).</p>