%0 Figure %A Ratai, Eva-Maria %A P. Bombardier, Jeffrey %A Joo, Chan-Gyu %A Annamalai, Lakshmanan %A H. Burdo, Tricia %A Campbell, Jennifer %A Fell, Robert %A Hakimelahi, Reza %A He, Julian %A Autissier, Patrick %A R. Lentz, Margaret %A F. Halpern, Elkan %A Masliah, Eliezer %A C. Williams, Kenneth %A V. Westmoreland, Susan %A Gilberto González, R. %D 2013 %T Minocycline reduces microglial activation, assessed by ionized calcium binding adaptor molecule 1 (IBA-1) expression. %U https://plos.figshare.com/articles/figure/_Minocycline_reduces_microglial_activation_assessed_by_ionized_calcium_binding_adaptor_molecule_1_IBA_1_expression_/521585 %R 10.1371/journal.pone.0010523.g007 %2 https://ndownloader.figshare.com/files/851164 %K microglial %K assessed %K ionized %K calcium %K binding %K adaptor %X

(A) IBA-1 expression in four representative sections from each of an uninfected, CD8-depleted animal (control), an untreated SIV-infected CD8-depleted animal (1308), a MN-treated persistently CD8-depleted animal (7307) and a MN-treated short-term CD8-depleted animal (7407). Visual inspection reveals less IBA-1 expression in the MN-treated animals. (B) Immunohistochemistry image analysis for IBA-1 in brain tissue sections of the frontal cortex. Data is given for four uninfected, CD8-depleted animals which served as controls (diamonds), four untreated SIV-infected CD8-depleted animals sacrificed at 8 wpi (solid squares) and four minocycline (MN)-treated (persistently CD8-depleted) animals. The mean for each cohort is given as a horizontal black line within its respective box. Upper and lower boundaries of the boxes correspond to a factor of 1.5 times the standard deviation. There was a statistically significant difference in frontal cortex IBA-1 levels among the three cohorts (p = 0.012). There are more IBA-1 positive particles/mm2 in the SIV-infected, CD8-depleted, untreated cohort compared to -uninfected, CD8-depleted controls (p = 0.004). There was no statistically significant difference in IBA-1 positive particles/mm2 in MN-treated animals compared to the uninfected CD8-depleted controls.

%I PLOS ONE