10.6084/m9.figshare.5212558
Quy Hung Trieu
Quy Hung
Trieu
Huong Doan Thi Mai
Huong
Doan Thi Mai
Marc Litaudon
Marc
Litaudon
Dao Phi Thi
Dao Phi
Thi
Tuan Anh Tran
Tuan Anh
Tran
Van Hung Nguyen
Van Hung
Nguyen
Van Minh Chau
Van Minh
Chau
Van Cuong Pham
Van Cuong
Pham
Two new linear acetogenins from the fruits of <i>Goniothalamus gracilipes</i>
Taylor & Francis Group
2017
Annonaceae
Goniothalamus gracilipes
Gracilipin A
methyl-saccopetrin A
cytotoxic activity
2017-07-17 06:21:53
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Two_new_linear_acetogenins_from_the_fruits_of_i_Goniothalamus_gracilipes_i_/5212558
<p>Two new linear acetogenins, gracilipin A (<b>1</b>) and methylsaccopetrin A (<b>2</b>) along with seven known compounds, saccopetrin A (<b>3</b>), 7,3′,4′-trimethylquercetin (<b>4</b>), rhamnazin (<b>5</b>), casticin (<b>6</b>), isokanugin (<b>7</b>), melisimplexin (<b>8</b>) and 5-hydroxy-3,7-dimethoxy-3′,4′-methylenedioxyflavone (<b>9</b>) were isolated from the fruits of <i>Goniothalamus gracilipes</i> Bân. Their structures were established by spectral analysis, such as mass spectrometry, 1D-NMR, 2D-NMR and circular dichroism (CD). Compounds <b>1</b> and <b>3</b> showed cytotoxic activity against KB cell line with IC<sub>50</sub> values of 14.6 and 15.3 μM, respectively.</p>