Couderc, Elodie Morel, Franck Levillain, Pierre Buffière-Morgado, Amandine Camus, Magalie Paquier, Camille Bodet, Charles Jégou, Jean-François Pohin, Mathilde Favot, Laure Garcia, Martine Huguier, Vincent Mcheik, Jiad Lacombe, Corinne Yssel, Hans Guillet, Gérard Bernard, François-Xavier Lecron, Jean-Claude A-SAA mRNA expression in the skin and the serum of psoriatic and control patients. <p>A-SAA mRNA expression in (A) the skin and (B) the serum of psoriatic patients is compared to healthy controls. Positive correlations of (C) serum A-SAA and CRP protein levels and (D) A-SAA mRNA expression in the skin and A-SAA protein concentrations in the serum of psoriatic patients. A-SAA mRNA levels from psoriatic skins are increased with (E) psoriasis severity, as evaluated by PASI, (F) disease duration, (G) cigarette smoking and (H) metabolic syndrome, respectively. A-SAA mRNA expression from 37 psoriatic skins was compared to 28 healthy skins and quantified by RT-qPCR. A-SAA protein concentrations in 17 psoriatic sera were determined by immunonephelemetry and compared to those of 11 healthy sera. Values are expressed as mean ± SEM. Statistical comparisons were performed using t test or Spearman rank correlation test (*p<0.05; **p<0.01; ***p<0.0001; ns, non-significant).</p> A-SAA expression;CCR;CCL;Interleukin -17A production;RT;Th 17 lymphocyte recruitment;Human Epidermal Keratinocytes;STAT;Th 17 lymphocytes;OSM;NF;ELISA;psoriasis pathogenesis Background Acute-serum Amyloid;AD;TNF;IL;NHEK 2017-07-14
    https://plos.figshare.com/articles/figure/A-SAA_mRNA_expression_in_the_skin_and_the_serum_of_psoriatic_and_control_patients_/5211280
10.1371/journal.pone.0181486.g004