%0 Figure %A Ries, Moritz %A R. Reynolds, Matthew %A Bashkueva, Ksenia %A Crosno, Kristin %A Capuano, Saverio %A Prall, Trent M. %A Wiseman, Roger %A H. O’Connor, David %A G. Rakasz, Eva %A Uno, Hajime %A D. Lifson, Jeffrey %A T. Evans, David %D 2017 %T Comparison of the frequencies of KIR3DL01+ and KIR3DL05+ NK cells in lymph nodes and gut-associated lymphoid tissues. %U https://plos.figshare.com/articles/figure/Comparison_of_the_frequencies_of_KIR3DL01_sup_sup_and_KIR3DL05_sup_sup_NK_cells_in_lymph_nodes_and_gut-associated_lymphoid_tissues_/5211247 %R 10.1371/journal.ppat.1006506.g007 %2 https://ndownloader.figshare.com/files/8972521 %K CD 107a %K TNF α upregulation %K HLA-DR %K NK cell activation %K NK cell responses %K NK cells %K Mamu-Bw 4 molecules %K interactions influence NK cell responses %K SIV infection %K KIR 3DL %K CD 16 %K KIR 3DL upregulation %K MHC class I-defined rhesus macaques Natural killer cells %K CD 56 %K polymorphic killer-cell immunoglobulin-like receptors %K gut-associated lymphoid tissues %K MHC class %X

The frequencies of KIR3DL05+ (A), KIR3DL01+ (B) and KIR3DL01-05- (C) NK cells in PBMCs, lymph nodes (LN) and gut-associated lymphoid tissues (GALT) were compared prior to SIV infection (week -4) and at weeks 2 and 8 after SIV infection. The frequencies of CD16+, CD56+ and CD16-CD56- NK cells in lymph nodes (D & E) and gut-associated lymphoid tissues (F & G) expressing KIR3DL05 (D & F) or KIR3DL01 (E & G) were also compared at weeks -4, 2 and 8 pre- and post-infection. Representative gating for differentiating KIR3DL01+ versus KIR3DL05+ NK cells in lymphocytes isolated from colorectal biopsies is illustrated in S7 Fig. Significant differences are indicated with asterisks (p<0.05*, p<0.01**, p< 0.005*** & p<0.001****, Mann-Whitney U-test). Samples with less than 30 events per gate were excluded from the analysis.

%I PLOS Pathogens