10.1371/journal.ppat.1006506.g006 Moritz Ries Moritz Ries Matthew R. Reynolds Matthew R. Reynolds Ksenia Bashkueva Ksenia Bashkueva Kristin Crosno Kristin Crosno Saverio Capuano III Saverio Capuano Trent M. Prall Trent M. Prall Roger Wiseman Roger Wiseman David H. O’Connor David H. O’Connor Eva G. Rakasz Eva G. Rakasz Hajime Uno Hajime Uno Jeffrey D. Lifson Jeffrey D. Lifson David T. Evans David T. Evans NK cell responses in tissues. Public Library of Science 2017 CD 107a TNF α upregulation HLA-DR NK cell activation NK cell responses NK cells Mamu-Bw 4 molecules interactions influence NK cell responses SIV infection KIR 3DL CD 16 KIR 3DL upregulation MHC class I-defined rhesus macaques Natural killer cells CD 56 polymorphic killer-cell immunoglobulin-like receptors gut-associated lymphoid tissues MHC class 2017-07-14 17:51:38 Figure https://plos.figshare.com/articles/figure/NK_cell_responses_in_tissues_/5211244 <p>The frequency of total NK cells in PBMCs, lymph nodes (LN) and gut-associated lymphoid tissues (GALT) (A), and of CD16<sup>+</sup>, CD56<sup>+</sup> and CD16<sup>-</sup>CD56<sup>-</sup> NK cells in LN (B) and GALT (C) during acute (week 2) and chronic (week 8) infection were compared to the frequency of these populations prior to SIV infection (week -4). Significant differences are indicated with asterisks (p<0.05*, p<0.01**, p< 0.005*** & p<0.001****, Mann-Whitney <i>U</i>-test).</p>