Use of Catalytic Static Mixers for Continuous Flow Gas–Liquid
and Transfer Hydrogenations in Organic Synthesis
Christian H. Hornung
Xuan Nguyen
Antony Carafa
James Gardiner
Andrew Urban
Darren Fraser
Mike D. Horne
Dayalan R. Gunasegaram
John Tsanaktsidis
10.1021/acs.oprd.7b00180.s001
https://acs.figshare.com/articles/journal_contribution/Use_of_Catalytic_Static_Mixers_for_Continuous_Flow_Gas_Liquid_and_Transfer_Hydrogenations_in_Organic_Synthesis/5203834
Catalytic
static mixers were used for the continuous flow hydrogenation of alkenes,
alkynes, carbonyls, nitro- and diazo-compounds, nitriles, imines,
and halides. This technique relies on tubular reactors fitted with
3D printed static mixers which are coated with a catalytic metal layer,
either Pd or Ni. Additive manufacturing of the metal mixer scaffold
results in maximum design flexibility and is compatible with deposition
methods such as metal cold spraying which allow for mass production
and linear process scale up. High to full conversion was achieved
for the majority of substrates, demonstrating the flexibility and
versatility of the catalytic static mixer technology. In the example
of an alkyne reduction, the selectivity of the flow reactor could
be directed to either yield an alkene or alkane product by simply
changing the reactor pressure.
2017-06-28 00:00:00
Organic Synthesis Catalytic
3 D
reactor pressure
Catalytic Static Mixers
deposition methods
process scale
flow hydrogenation
Additive manufacturing
alkene
metal layer
design flexibility
alkyne reduction
flow reactor
Transfer Hydrogenations
alkane product
mass production
mixer technology
metal mixer scaffold results