TY - DATA T1 - Changes in EPSC parameters have little effect on the ISI distribution. PY - 2017/07/06 AU - Trystan Leng AU - Gareth Leng AU - Duncan J. MacGregor UR - https://plos.figshare.com/articles/figure/Changes_in_EPSC_parameters_have_little_effect_on_the_ISI_distribution_/5180029 DO - 10.1371/journal.pone.0180368.g007 L4 - https://ndownloader.figshare.com/files/8837101 KW - HH model parameters KW - ISI KW - HH model KW - oxytocin neurons KW - integrate-and-fire models Integrate-and-fire KW - HH model representation KW - HAP KW - spike patterning KW - AHP N2 - We investigated how changes to the EPSC parameters affect the ISI distribution in the HH model when the spike rate is kept constant at 9 spikes/s. (A) Increasing the EPSC magnitude (Δepsc) slightly increases the number of short ISIs, shifting the distribution to the left, with a small decrease in the height of the mode. Plotted distributions are for EPSP magnitudes of ~ 1, 2, 3, and 4 mV (darkest to lightest). The changes in EPSPs that result from the changes in kepsc are plotted on the right. EPSC rates (Repsc = 2920, 1294, 774 and 526 Hz respectively) were adjusted to achieve a firing rate of 9 spikes/s. (B) Increasing the EPSC time-constant (τepsc) very slightly increases the number of short ISIs, shifting the distribution to the left, with a small decrease in the height of the mode. Plotted distributions are for τepsc = 1.1, 2.2, 3.3, and 4.4 ms (yellow to dark red). The changes in EPSPs that result from the changes in τepsc are plotted on the right. EPSC rates (Repsc = 2685, 1220, 774, and 567 Hz respectively) were adjusted to achieve a firing rate of 9 spikes/s. ER -