10.1371/journal.pcbi.1005482.g006 Kamran Kaveh Kamran Kaveh Yutaka Takahashi Yutaka Takahashi Michael A. Farrar Michael A. Farrar Guy Storme Guy Storme Marcucci Guido Marcucci Guido Jamie Piepenburg Jamie Piepenburg Jackson Penning Jackson Penning Jasmine Foo Jasmine Foo Kevin Z. Leder Kevin Z. Leder Susanta K. Hui Susanta K. Hui Radiation and Nilotinib dose responses. Public Library of Science 2017 drug-resistance Philadelphia chromosome-positive Nilotinib LDR TKI Decreased expression level combination therapy cell viability experiments tyrosine kinase inhibitor AKT lymphoblastic leukemia model 2017-07-06 17:25:09 Figure https://plos.figshare.com/articles/figure/Radiation_and_Nilotinib_dose_responses_/5179150 <p>a) Radiation dose-response curve under no Nilotinib treatment (magenta) and 18 nM Nilotinib (red). Solid lines are model predictions with independently fitted parameters (from Tables <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1005482#pcbi.1005482.t001" target="_blank">1</a> and <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1005482#pcbi.1005482.t002" target="_blank">2</a>). Experimental data shown in circles. Cell viabilities are measured after three days. b) Nilotinib dose-response curves in absence of radiation. Solid lines are model predictions with independently fitted parameters, experimental data shown in circles. Cell viabilities are measured after three days. Other lines represent model predictions for efficacy of Nilotinib treatment combined with various radiation doses of 1, 2, 3 and 4 Gy.</p>