10.1371/journal.pcbi.1005482.g006
Kamran Kaveh
Kamran
Kaveh
Yutaka Takahashi
Yutaka
Takahashi
Michael A. Farrar
Michael A.
Farrar
Guy Storme
Guy
Storme
Marcucci Guido
Marcucci
Guido
Jamie Piepenburg
Jamie
Piepenburg
Jackson Penning
Jackson
Penning
Jasmine Foo
Jasmine
Foo
Kevin Z. Leder
Kevin Z.
Leder
Susanta K. Hui
Susanta
K. Hui
Radiation and Nilotinib dose responses.
Public Library of Science
2017
drug-resistance Philadelphia chromosome-positive
Nilotinib
LDR
TKI
Decreased expression level
combination therapy
cell viability experiments
tyrosine kinase inhibitor
AKT
lymphoblastic leukemia
model
2017-07-06 17:25:09
Figure
https://plos.figshare.com/articles/figure/Radiation_and_Nilotinib_dose_responses_/5179150
<p>a) Radiation dose-response curve under no Nilotinib treatment (magenta) and 18 nM Nilotinib (red). Solid lines are model predictions with independently fitted parameters (from Tables <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1005482#pcbi.1005482.t001" target="_blank">1</a> and <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1005482#pcbi.1005482.t002" target="_blank">2</a>). Experimental data shown in circles. Cell viabilities are measured after three days. b) Nilotinib dose-response curves in absence of radiation. Solid lines are model predictions with independently fitted parameters, experimental data shown in circles. Cell viabilities are measured after three days. Other lines represent model predictions for efficacy of Nilotinib treatment combined with various radiation doses of 1, 2, 3 and 4 Gy.</p>