%0 Figure %A Skalska, Lenka %A E. White, Robert %A Franz, Melanie %A Ruhmann, Michaela %A J. Allday, Martin %D 2010 %T EBNA3A contributes to the regulation of p16INK4A. %U https://plos.figshare.com/articles/figure/_EBNA3A_contributes_to_the_regulation_of_p16_INK4A_/516910 %R 10.1371/journal.ppat.1000951.g007 %2 https://ndownloader.figshare.com/files/846453 %K contributes %X

(A) Western blot analysis of three LCLs established with virus derived from B95.8-EBV BAC (WT) and two established with EBNA3A-KO recombinants. The steady state levels of p16INK4A (p16) are elevated in the EBNA3A-KO cells relative to the WT-EBV infected cells. It should be noted that similar results were reported using a larger panel of EBNA3A-KO LCLs [8]. An LCL 3CHT (3CHT) with (+) or without (-) HT is shown for comparison. (B) & (C) ChIP analysis of H3K27me3 and H3K4me3 distribution on exon 1 (site C) and site A in the p16INK4A-ARF locus from an EBNA3A-KO LCL (3AKO) and a WT-EBV LCL (WT).

%I PLOS Pathogens