TY - DATA T1 - Additional file 1: Figures S1–S6. of A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation PY - 2017/06/26 AU - Srikant Rangaraju AU - Syed Raza AU - Andrea Pennati AU - Qiudong Deng AU - Eric Dammer AU - Duc Duong AU - Michael Pennington AU - Malu Tansey AU - James Lah AU - Ranjita Betarbet AU - Nicholas Seyfried AU - Allan Levey UR - https://springernature.figshare.com/articles/journal_contribution/Additional_file_1_Figures_S1_S6_of_A_systems_pharmacology-based_approach_to_identify_novel_Kv1_3_channel-dependent_mechanisms_in_microglial_activation/5146618 DO - 10.6084/m9.figshare.c.3811411_D1.v1 L4 - https://ndownloader.figshare.com/files/8759287 KW - Microglia KW - Neuroinflammation KW - Potassium channels KW - Kv1.3 KW - Proteomics N2 - Flow cytometric confirmation of Kv1.3-channel specificity of the ShK-F6CA binding assay is shown in Figure S1. Comparison of ShK-F6CA labeling of Kv1.3 channels in splenic and brain-infiltrating macrophages is shown in Figure S2. Morphological changes induced by LPS, ShK-223, and LPS+ShK-223 treatment conditions are shown in Figure S3. Distribution of missing data in the proteomic data set is shown in Figure S4. Quantitative RT-PCR data showing validation of pro-inflammatory activation of BV2 microglia by LPS are shown in Figure S5. EHD1 upregulation by LPS and inhibition of EHD1 upregulation by ShK-223 is shown in Figure S6. (DOCX 1262 kb) ER -