A new <i>ent</i>-kaurane diterpene derivative from the stems of <i>Eurya chinensis</i> R.Br
Jia-Ling Song
Yao Yuan
Ling-Hui Nie
Bai-Lin Li
Xu-Bing Qin
Yan Li
Jie-Wei Wu
Sheng-Xiang Qiu
10.6084/m9.figshare.5139724
https://tandf.figshare.com/articles/journal_contribution/A_new_i_ent_i_-kaurane_diterpene_derivative_from_the_stems_of_i_Eurya_chinensis_i_R_Br/5139724
<p>One new <i>ent</i>-kaurane diterpene derivative (<b>1</b>), along with four known diterpenes, was isolated from the stems of <i>Eurya chinensis</i> R.Br. The structure of the new compound was established by extensive analysis of mass spectrometric and 1D and 2D NMR spectroscopic data. Compound <b>1</b> showed moderate anti-inflammatory activities with IC<sub>50</sub> value of 8.12 μM. This is the first example of diterpenoids with 4-hydroxy-4-(2-hydroxyethyl)-1-hydroxyl-cyclohexanoyl substituent.</p>
2017-06-23 07:21:30
Eurya chinensis
diterpene
derivative
anti-inflammatory