TY - DATA T1 - Various oncogenes in triple-negative breast cancer (TNBC). PY - 2017/06/21 AU - Masahito Kawazu AU - Shinya Kojima AU - Toshihide Ueno AU - Yasushi Totoki AU - Hiromi Nakamura AU - Akiko Kunita AU - Wei Qu AU - Jun Yoshimura AU - Manabu Soda AU - Takahiko Yasuda AU - Natsuko Hama AU - Mihoko Saito-Adachi AU - Kazuhito Sato AU - Shinji Kohsaka AU - Eirin Sai AU - Masako Ikemura AU - Shigeru Yamamoto AU - Tomoko Ogawa AU - Masashi Fukayama AU - Keiichiro Tada AU - Yasuyuki Seto AU - Shinichi Morishita AU - Shoichi Hazama AU - Tatsuhiro Shibata AU - Yoshihiro Yamashita AU - Hiroyuki Mano UR - https://plos.figshare.com/articles/figure/Various_oncogenes_in_triple-negative_breast_cancer_TNBC_/5133094 DO - 10.1371/journal.pgen.1006853.g005 L4 - https://ndownloader.figshare.com/files/8831011 KW - RB 1 KW - 3 T 3 mouse fibroblasts KW - exome sequencing KW - genome sequencing KW - TP 53 mutations KW - MYC KW - driver event KW - CpG dinucleotides KW - Integrative analysis KW - tandem duplication KW - NOTCH 3 KW - recombination pathway KW - PTEN KW - epidermal growth factor receptor 2. KW - poly ADP-ribose polymerase inhibitors KW - affinity ligands KW - epidermal growth factor receptor KW - BRCA 1 mutations KW - NOTCH 2 KW - TGFA oncogene KW - Clonal analysis KW - driver oncogenic events KW - estrogen receptors KW - tumor suppressor genes KW - TNBC tumors KW - recombination deficiency Triple-negative breast cancer KW - Recurrent SVs KW - BRCA 1 gene KW - triple-negative breast cancer KW - BRCA 1 promoter KW - TGFA enhancer regions KW - progesterone receptors KW - KMT 2C KW - genomic alterations KW - TGFA enhancer region N2 - (A) NFKB1 mutations found in this study (above, TNBC) and in the TCGA data (below, various cancers). (B) Mutations in NOTCH1 found in this study (above, TNBC) and in the TCGA data (below, TNBC). (C) Mutations in ERBB2 found in this study (above, TNBC) and in the TCGA data (below, BC). (D) Diagram of the protein encoded by the FGFR3-CAT fusion gene. IG, immunoglobulin-like domain; TyrKc, tyrosine-protein kinase catalytic domain. (E) Anchorage-independent growth of 3T3 cells expressing the indicated proteins. The diagrams of the proteins in (A), (B), and (C) were generated using protein painter (http://explore.pediatriccancergenomeproject.org/proteinPainter). Mutations expected to be activating according to previous reports or experiments in this study are highlighted in red. ER -