TY - DATA T1 - Supplementary Material for: A Common Genetic Variant in the Insulin Receptor Gene Is Associated with Eating Difficulties at 2 Years of Age in a Cohort of Preterm Infants PY - 2015/12/03 AU - Amarger V. AU - Bouvagnet A. AU - Moyon T. AU - Vaiman D. AU - Darmaun D. AU - de Lauzon-Guillain B. AU - Robitaille J. AU - Flamant C AU - Rozé J.-C. AU - Parnet P. UR - https://karger.figshare.com/articles/dataset/Supplementary_Material_for_A_Common_Genetic_Variant_in_the_Insulin_Receptor_Gene_Is_Associated_with_Eating_Difficulties_at_2_Years_of_Age_in_a_Cohort_of_Preterm_Infants/5129065 DO - 10.6084/m9.figshare.5129065.v1 L4 - https://ndownloader.figshare.com/files/8717515 KW - Eating behavior KW - Genetics KW - Insulin receptor KW - Preterm infants KW - Single nucleotide polymorphisms N2 - Background/Aims: Children born preterm are more likely than full-term infants to develop eating difficulties that can affect their growth. Although this behavior is certainly influenced by their fetal and postnatal history, a large individual variability exists that results from a complex interaction between genetic and environmental factors. We performed an original pilot study to identify common genetic variants associated with eating difficulties at 2 years of age in the POLYNUCA cohort of preterm infants. Methods: Eating behavior was assessed using a parental questionnaire in a cohort of 234 very preterm infants (including 38 pairs of twins). Eighty-two common single nucleotide polymorphisms (SNPs) were selected in a total of 40 candidate genes involved in the regulation of energy homeostasis and food intake. Results: Eating behavior was strongly correlated in monozygotic (r = 0.92, p = 0.001) but not dizygotic twins (r = 0.27, p = 0.14), suggesting a strong heritability of this trait. One SNP (rs11671975) in the insulin receptor (INSR) gene was significantly associated with eating behavior. This effect was maintained after adjustment for birth weight Z score and maternal education level, two factors that are associated with eating difficulties at 2 years of age. Conclusion: The INSR gene is potentially associated with eating difficulties in preterm infants. ER -