Supplementary Material for: Comparison of Safety and Efficacy of Different Models of Target Vessel Regional Chemotherapy for Gastric Cancer with Liver Metastases Chen H. Gao S. Yang X.-Z. Chen L.-J. Liu P. Xu H.-F. 10.6084/m9.figshare.5128813.v1 https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Comparison_of_Safety_and_Efficacy_of_Different_Models_of_Target_Vessel_Regional_Chemotherapy_for_Gastric_Cancer_with_Liver_Metastases/5128813 <b><i>Background/Aims:</i></b> We previously demonstrated the safety and efficacy of low-dose, short-interval target vessel regional chemotherapy (TVRC<sup>LDSI</sup>) delivered through the hepatic artery with transarterial embolization (TAE) in patients with advanced gastric cancer (AGC). The present study aimed to compare the efficacy of TAE + TVRC<sup>LDSI</sup> with that of standard TAE + TVRC in AGC patients with liver metastases who failed to respond to first- or second-line systemic chemotherapy. <b><i>Methods:</i></b> This study recruited a total of 58 GC patients with liver metastases after failure of first- or second-line systemic chemotherapy. Twenty-eight patients were assigned to the TAE + TVRC<sup>LDSI</sup> group and 30 patients to the TAE + TVRC group. The primary end point was overall survival (OS<sup>TVRC</sup>), which was defined as the time from the initiation of TVRC until the last follow-up or death. <b><i>Results:</i></b> OS<sup>TVRC</sup>, time to progression (TTP) until appearance of intra- and extrahepatic metastases, and overall TTP and treatment periods in the TAE + TVRC<sup>LDSI</sup> group were all significantly longer than in the TAE + TVRC group (all p < 0.001). <b><i>Conclusion:</i></b> TAE + TVRC<sup>LDSI</sup> had a higher efficacy and safety, which was reflected by OS rates, progression-free survival rates, longer duration of treatment and milder side effects compared to standard TAE + TVRC. 2015-12-01 00:00:00 Overall survival Advanced gastric cancer Target vessel regional chemotherapy Transarterial embolization Liver metastases Transcatheter arterial chemoembolization