10.6084/m9.figshare.5128591.v1 Cavkaytar O. Cavkaytar O. Arik Yilmaz E. Arik Yilmaz E. Karaatmaca B. Karaatmaca B. Buyuktiryaki B. Buyuktiryaki B. Sackesen C. Sackesen C. Sekerel B.E. Sekerel B.E. Soyer O. Soyer O. Supplementary Material for: Different Phenotypes of Non-Steroidal Anti-Inflammatory Drug Hypersensitivity during Childhood Karger Publishers 2015 Paediatric patients Cross-reactivity Drug hypersensitivity Non-steroidal anti-inflammatory drugs Selective responders 2015-08-29 00:00:00 Dataset https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Different_Phenotypes_of_Non-Steroidal_Anti-Inflammatory_Drug_Hypersensitivity_during_Childhood/5128591 <b><i>Background:</i></b> Although non-steroidal anti-inflammatory drug hypersensitivity (NSAID-H) has been widely studied in adults, there is still a lack of data regarding the features and phenotypes of NSAID-H in children. Our aim was to define risk factors and different phenotypes according to clinical patterns. <b><i>Methods:</i></b> Patients with a history of reaction to any NSAIDs referred between January 2012 and October 2014 were included. After completing a European Network for Drug Allergy (ENDA) questionnaire, initial skin and/or oral provocation tests (OPTs) were performed for the offending drug. Additional OPTs were done with aspirin in case of NSAID-H to determine cross-reactivity. NSAID-hypersensitive patients were defined as being either a selective responder (SR) or cross-intolerant (CI) and further categorized according to either the ENDA/GA<sup>2</sup>LEN classification or an alternative scheme by Caimmi et al. [Int Arch Allergy Immunol 2012;159:306-312]. <b><i>Results:</i></b> Among 121 patients [58.7% male, average age 7.8 years (4.7-10.8)] with 161 NSAID-related reactions, 110 patients with 148 reactions were assessed. NSAID-H was diagnosed in 30 (27%) patients with 37 (25%) reactions. Multivariate regression analysis revealed that an immediate-type reaction and respiratory symptoms during the reaction increased the risk of a reproducible NSAID-related reaction (OR 3.508, 95% CI 1.42-8.7, p = 0.007; OR 3.951, 95% CI 1.33-11.77, p = 0.014, respectively). Additional OPTs revealed 13 SRs and 14 CIs. A family history of allergic disease was more frequent in CIs compared to SRs (57.1 vs. 15.4%, p = 0.031). Reactions belonging to CIs were more frequently characterized by angioedema compared to those of SRs (81.3 vs. 46.2%, p = 0.019). SRs and CIs were further classified as single NSAID-induced urticaria/angioedema and/or anaphylaxis (n = 13), NSAID-induced urticaria/angioedema (n = 7), NSAID-exacerbated cutaneous disease (n = 2) and NSAID-exacerbated respiratory disease (n = 1). Four CIs could not be categorized according to either classification system. One SR could not be categorized according to ENDA/GA<sup>2</sup>LEN. <b><i>Conclusion:</i></b> During childhood, NSAID-H exhibits different phenotypes and the majority of them can be categorized with current classification systems; however, classifications based on adult data may not exactly fit NSAID-H in paediatric patients.