%0 Generic
%A I., Rudkowska
%A L., Pérusse
%A C., Bellis
%A J., Blangero
%A J.-P., Després
%A C., Bouchard
%A M.-C., Vohl
%D 2015
%T Supplementary Material for: Interaction between Common Genetic Variants and Total Fat Intake on Low-Density Lipoprotein Peak Particle Diameter: A Genome-Wide Association Study
%U https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Interaction_between_Common_Genetic_Variants_and_Total_Fat_Intake_on_Low-Density_Lipoprotein_Peak_Particle_Diameter_A_Genome-Wide_Association_Study/5128159
%R 10.6084/m9.figshare.5128159.v1
%2 https://ndownloader.figshare.com/files/8716216
%K Genome-wide analysis study
%K Total fat intake
%K Low-density lipoprotein peak particle size
%K Nutrigenetics
%K Single nucleotide polymorphisms
%X Background/Aim: Total fat intake has an important impact on the low-density lipoprotein (LDL) peak particle diameter (LDL-PPD) and may interact with nutrient-sensitive single nucleotide polymorphisms (SNPs). The objective was to examine whether there is suggestive evidence of SNP × dietary fat intake interaction effects influencing the LDL-PPD in the Quebec Family Study (QFS) in order to generate hypotheses to be tested in larger studies. Methods: SNPs from a genome-wide association study (GWAS) using Illumina Human610-Quad BeadChip, total fat intake derived from a 3-day weighted food record, and SNP × total fat intake interaction effects were examined on LDL-PPD in 541 QFS subjects. Results: The GWAS analyses 29 identified independent SNP × total fat intake interaction effects on the LDL-PPD at p < 10-5, including SNPs in the following genes: ABCG2, CPA3, FNBP1, KCNQ3, NBAS, NCALD, OPRL1, NKAIN2, SH3BGRL2, SOX5, and SUSD4. Conclusions: This observational study suggests that multiple SNPs interact with dietary fat intake to influence variation in the LDL-PPD.
%I Karger Publishers