%0 Generic
%A M., Pietzner
%A G., Homuth
%A K., Budde
%A I., Lehmphul
%A U., Völker
%A H., Völzke
%A M., Nauck
%A J., Köhrle
%A N., Friedrich
%D 2015
%T Supplementary Material for: Urine Metabolomics by 1H-NMR Spectroscopy Indicates Associations between Serum 3,5-T2 Concentrations and Intermediary Metabolism in Euthyroid Humans
%U https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Urine_Metabolomics_by_sup_1_sup_H-NMR_Spectroscopy_Indicates_Associations_between_Serum_3_5-T_sub_2_sub_Concentrations_and_Intermediary_Metabolism_in_Euthyroid_Humans/5127835
%R 10.6084/m9.figshare.5127835.v1
%2 https://ndownloader.figshare.com/files/8715751
%K 3,5-Diiodothyronine
%K Trigonelline
%K Urine metabolome
%K NMR spectroscopy
%K Thyroid hormone
%X Context: 3,5-Diiodo-L-thyronine (3,5-T2) is a thyroid hormone metabolite which exhibited versatile effects in rodent models, including the prevention of insulin resistance or hepatic steatosis typically forced by a high-fat diet. With respect to euthyroid humans, we recently observed a putative link between serum 3,5-T2 and glucose but not lipid metabolism. Objective: The aim of the present study was to widely screen the urine metabolome for associations with serum 3,5-T2 concentrations in healthy individuals. Study Design and Methods: Urine metabolites of 715 euthyroid participants of the population-based Study of Health in Pomerania (SHIP-TREND) were analyzed by 1H-NMR spectroscopy. Multinomial logistic and multivariate linear regression models were used to detect associations between urine metabolites and serum 3,5-T2 concentrations. Results: Serum 3,5-T2 concentrations were positively associated with urinary levels of trigonelline, pyroglutamate, acetone and hippurate. In detail, the odds for intermediate or suppressed serum 3,5-T2 concentrations doubled owing to a 1-standard deviation (SD) decrease in urine trigonelline levels, or increased by 29-50% in relation to a 1-SD decrease in urine pyroglutamate, acetone and hippurate levels. Conclusion: Our findings in humans confirmed the metabolic effects of circulating 3,5-T2 on glucose and lipid metabolism, oxidative stress and enhanced drug metabolism as postulated before based on interventional pharmacological studies in rodents. Of note, 3,5-T2 exhibited a unique urinary metabolic profile distinct from previously published results for the classical thyroid hormones.
%I Karger Publishers