%0 Generic
%A K., Albertsson-Wikland
%A B., Kriström
%A E., Lundberg
%A A.S., Aronson
%A J., Gustafsson
%A L., Hagenäs
%A S.-A., Ivarsson
%A B., Jonsson
%A M., Ritzén
%A T., Tuvemo
%D 2014
%T Supplementary Material for: Growth Hormone Dose-Dependent Pubertal Growth: A Randomized Trial in Short Children with Low Growth Hormone Secretion
%U https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Growth_Hormone_Dose-Dependent_Pubertal_Growth_A_Randomized_Trial_in_Short_Children_with_Low_Growth_Hormone_Secretion/5126557
%R 10.6084/m9.figshare.5126557.v1
%2 https://ndownloader.figshare.com/files/8713948
%K Gain in height
%K Prepubertal growth
%K Growth hormone frequency
%K Delayed infancy-childhood transition
%K Puberty
%X Background/Aims: Growth hormone (GH) treatment regimens do not account for the pubertal increase in endogenous GH secretion. This study assessed whether increasing the GH dose and/or frequency of administration improves pubertal height gain and adult height (AH) in children with low GH secretion during stimulation tests, i.e. idiopathic isolated GH deficiency. Methods: A multicenter, randomized, clinical trial (No. 88-177) followed 111 children (96 boys) at study start from onset of puberty to AH who had received GH 33 µg/kg/day for ≥1 year. They were randomized to receive 67 µg/kg/day (GH67) given as one (GH67×1; n = 35) or two daily injections (GH33×2; n = 36), or to remain on a single 33 µg/kg/day dose (GH33×1; n = 40). Growth was assessed as heightSDSgain for prepubertal, pubertal and total periods, as well as AHSDS versus the population and the midparental height. Results: Pubertal heightSDSgain was greater for patients receiving a high dose (GH67, 0.73) than a low dose (GH33×1, 0.41, p < 0.05). AHSDS was greater on GH67 (GH67×1, -0.84; GH33×2, -0.83) than GH33 (-1.25, p < 0.05), and heightSDSgain was greater on GH67 than GH33 (2.04 and 1.56, respectively; p < 0.01). All groups reached their target heightSDS. Conclusion: Pubertal heightSDSgain and AHSDS were dose dependent, with greater growth being observed for the GH67 than the GH33 randomization group; however, there were no differences between the once- and twice-daily GH67 regimens.
%I Karger Publishers