TY - DATA T1 - Supplementary Material for: Circulating Matrix Metalloproteinase-9 Level Is Associated with Cerebral White Matter Hyperintensities in Non-Stroke Individuals PY - 2014/09/20 AU - Kim Y. AU - Kim Y.-K. AU - Kim N.K. AU - Kim S.-H. AU - Kim O.-J. AU - Oh S.-H. UR - https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Circulating_Matrix_Metalloproteinase-9_Level_Is_Associated_with_Cerebral_White_Matter_Hyperintensities_in_Non-Stroke_Individuals/5126539 DO - 10.6084/m9.figshare.5126539.v1 L4 - https://ndownloader.figshare.com/files/8713927 KW - Cerebral white matter hyperintensities KW - Matrix metalloproteinase-9 KW - Blood-brain barrier KW - Small vessel disease N2 - Backgrounds: The pathogenesis of cerebral white matter hyperintensities (WMH) has been poorly understood. Our aim was to investigate the association of circulating proteins, the biomarkers of inflammation, blood-brain barrier (BBB) dysfunction, and thrombosis with WMH in non-stroke individuals. Methods: Demographic, laboratory, and brain magnetic resonance imaging parameters were prospectively analyzed in 137 subjects. The relationship between plasma interleukin-6, tumor necrosis factor-α, matrx-metalloproteinase-9 (MMP-9), plasminogen activator inhibitor-1 and overt WMH (Fazekas grading score ≥2) was analyzed. Results: In univariate analysis, old age, high blood pressure, history of hypertension, and elevated plasma MMP-9 level were associated with overt WMH. In multivariate analysis, plasma MMP-9 still maintained a significant association with WMH. Plasma MMP-9 level was weakly but significantly associated with WMH volume (r = 0.232, p = 0.006). All the other circulating proteins examined failed to demonstrate a significant relationship with WMH. Conclusions: Plasma MMP-9 is associated with pathophysiology of WMH development. ER -