%0 Generic
%A Z.-J., Deng
%A K.-Q., Shi
%A Y.-J., Song
%A Y.-X., Fang
%A J., Wu
%A G., Li
%A K.-F., Tang
%A J., Qu
%D 2014
%T Supplementary Material for: Association between a Lumican Promoter Polymorphism and High Myopia in the Chinese Population: A Meta-Analysis of Case-Control Studies
%U https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Association_between_a_Lumican_Promoter_Polymorphism_and_High_Myopia_in_the_Chinese_Population_A_Meta-Analysis_of_Case-Control_Studies/5125879
%R 10.6084/m9.figshare.5125879.v1
%2 https://ndownloader.figshare.com/files/8713030
%K Lumican
%K Single-nucleotide polymorphisms
%K High myopia
%K Axial length
%X Purpose: To evaluate the relationship between lumican polymorphisms and high myopia in Chinese populations. Methods: An electronic search was conducted in Pubmed, Embase, Cochrane Library and the China Biological Medicine Database for articles published prior to September 30, 2012. A meta-analysis was performed to assess heterogeneity, combine results and determine publication bias. Results: This meta-analysis, including 1,545 subjects from 5 studies, indicated that Chinese lumican rs3759223 C allele carriers had a decreased risk of high myopia in comparison to T allele carriers (odds ratio: 0.531; 95% confidence interval, CI: 0.304-0.925; p = 0.025). There was some heterogeneity between studies. A metaregression showed that the mean axial length of controls weakens the effect of rs3759223 on high myopia (slope: -0.914; 95% CI: -1.490 to 0.337; p = 0.002). Sensitivity analysis confirmed the reliability and stability of this meta-analysis. Conclusion: Chinese lumican rs3759223 C allele carriers may be at reduced risk of high myopia.
%I Karger Publishers