%0 Generic
%A K.L., Lentine
%A E., Anyaegbu
%A A., Gleisner
%A M.A., Schnitzler
%A D., Axelrod
%A D.C., Brennan
%A V.R., Dharnidharka
%A E., Abraham
%A J.E., Tuttle-Newhall
%D 2013
%T Supplementary Material for: Understanding Medical Care of Transplant Recipients through Integrated Registry and Pharmacy Claims Data
%U https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Understanding_Medical_Care_of_Transplant_Recipients_through_Integrated_Registry_and_Pharmacy_Claims_Data/5125768
%R 10.6084/m9.figshare.5125768.v1
%2 https://ndownloader.figshare.com/files/8712895
%K Antihypertensive agents
%K Comorbidity
%K Drug prescriptions
%K Kidney transplantation
%K Glomerular filtration rate
%K Pharmacy claims
%K Process assessment
%K Registries
%K Statins
%X Background: Limited data exist on medication use aside from immunosuppression among large samples of kidney transplant recipients. Methods: We examined a novel database wherein Organ Procurement and Transplantation Network (OPTN) registry data were linked to records from a US pharmaceutical claims clearinghouse (2005-2010 claims) to examine pharmaceutical care at the first transplant anniversary (n = 16,157). We quantified the use of the following medication types within ±60 days of the first-year OPTN report according to estimated glomerular filtration rate (eGFR): antihypertensives, lipid-lowering, bone and mineral, and anemia treatments. Adjusted associations of medication use with eGFR and other clinical factors were quantified by multivariate logistic regression. Results: Requirements for multiple antihypertensive agents rose with lower eGFR, with β-blockers comprising the most commonly used antihypertensive agent. The adjusted likelihood of vitamin D (adjusted odds ratio (aOR) 2.07, 95% CI 1.19-3.59) and especially erythrocyte-stimulating agents (aOR 19.94, 95% CI 7.01-56.00) rose in a graded manner to peak with eGFR <15 versus >90, whereas statin use was most common with eGFR 30-59 ml/min/1.73 m2. Black race was independently associated with increased use of all classes of antihypertensives and vitamin D, but lower adjusted statin use. Rapamycin-based immunosuppression was associated with increased use of statins and erythrocyte-stimulating agents. Conclusions: Integrated registry and pharmacy fill data provide a novel tool for pharmacoepidemiologic investigations of delivered post-transplant care. Transplant recipients with reduced renal function have increased requirements for pharmaceutical care of comorbidities. Causes of racial variation in medication fills warrant further investigation.
%I Karger Publishers