10.6084/m9.figshare.5124592.v1 Li J. Li J. Hou R. Hou R. Yang Y. Yang Y. Liu R. Liu R. Zhao X. Zhao X. Li X. Li X. Yin G. Yin G. An P. An P. Wang Y. Wang Y. Zhang K. Zhang K. Supplementary Material for: Narrowband Ultraviolet B Interferes with Gene Expression in the Peripheral Blood T Cells of Patients with Psoriasis Karger Publishers 2013 Psoriasis Narrowband ultraviolet B T cells Differentially expressed genes 2013-04-25 00:00:00 Dataset https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Narrowband_Ultraviolet_B_Interferes_with_Gene_Expression_in_the_Peripheral_Blood_T_Cells_of_Patients_with_Psoriasis/5124592 <b><i>Background:</i></b> Psoriasis pathogenesis and development are closely related to abnormal T cell activity. Narrowband ultraviolet B (NB-UVB) treatment markedly improves skin lesions in psoriasis. <b><i>Objectives:</i></b> To investigate differential gene expression in psoriasis and to understand the possible mechanisms of NB-UVB therapy for psoriasis. <b><i>Methods:</i></b> The mRNA expression profiles and differentially expressed genes from peripheral blood T cells of psoriatic patients before and after NB-UVB treatment were examined using RNA sequencing and validated by real-time reverse-transcription polymerase chain reaction. <b><i>Results:</i></b> A total of 129 genes were differentially expressed in the peripheral blood T cells of psoriatic patients: 83 genes were downregulated and 46 were upregulated in psoriatic patients compared to those of healthy subjects. These genes were enriched in intracellular membrane-bound organelles, membrane-bound organelles and the nucleus, and are involved in the cell cycle, apoptosis, inflammation and other processes. These changes are reversed in psoriatic patients with good clinical outcomes following NB-UVB treatment. <b><i>Conclusion:</i></b> NB-UVB treatment has beneficial effects on local psoriatic lesions, possibly due to its effect on peripheral blood T cell gene expression.