TY - DATA T1 - Supplementary Material for: Predictors of 1-Year Mortality at Hospital Admission for Acute Exacerbations of Chronic Obstructive Pulmonary Disease PY - 2012/10/02 AU - Slenter R.H.J. AU - Sprooten R.T.M. AU - Kotz D. AU - Wesseling G. AU - Wouters E.F.M. AU - Rohde G.G.U. UR - https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Predictors_of_1-Year_Mortality_at_Hospital_Admission_for_Acute_Exacerbations_of_Chronic_Obstructive_Pulmonary_Disease/5123899 DO - 10.6084/m9.figshare.5123899.v1 L4 - https://ndownloader.figshare.com/files/8710078 KW - Chronic obstructive pulmonary disease KW - Exacerbation KW - Predictor KW - Mortality KW - Gender N2 - Background: Acute exacerbations of chronic obstructive pulmonary disease (AE-COPD) are related to high mortality, especially in hospitalized patients. Predictors for severe outcomes are still not sufficiently defined. Objectives: To assess the mortality rate and identify potential determinants of mortality in a cohort of patients hospitalized for AE-COPD. Methods: A retrospective, observational cohort study including all consecutive patients admitted between January 1, 2009, and April 1, 2010, for AE-COPD. Potential predictors were assessed at initial presentation at the emergency room. The primary outcome was mortality during 1-year follow-up. Univariate and multivariate time-to-event analyses using Cox proportional hazard models were employed for statistical analysis. Results: A total of 260 patients were enrolled in this study. Mean age was 70.5 ± 10.8 years, 50.0% were male and 63.4% had severe COPD. The in-hospital mortality rate was 5.8% and the 1-year mortality rate was 27.7%. Independent risk factors for mortality were age [hazard ratio (HR) = 1.04; 95% confidence interval (CI) = 1.01–1.07], male sex (HR = 2.00; 95% CI = 1.15–3.48), prior hospitalization for AE-COPD in the last 2 years (HR = 2.56; 95% CI = 1.52–4.30), prior recorded congestive heart failure (HR = 1.75; 95% CI = 1.03–2.97), Paco2 ≥6.0 kPa (HR = 2.90; 95% CI = 1.65–5.09) and urea ≥8.0 mmol/l (HR = 2.38; 95% CI = 1.42–3.99) at admission. Conclusions: Age, male sex, prior hospitalization for AE-COPD in the last 2 years, prior recorded congestive heart failure, hypercapnia and elevated levels of urea at hospital admission are independent predictors of mortality within the first year after admission. ER -