Supplementary Material for: Heart Rate Response to a Timed Walk and Cardiovascular Outcomes in Older Adults: The Cardiovascular Health Study Girotra S. Kitzman D.W. Kop W.J. Stein P.K. Gottdiener J.S. Mukamal K.J. 10.6084/m9.figshare.5123566.v1 https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Heart_Rate_Response_to_a_Timed_Walk_and_Cardiovascular_Outcomes_in_Older_Adults_The_Cardiovascular_Health_Study/5123566 <b><i>Objectives:</i></b> To determine the relationship between heart rate response during low-grade physical exertion (6-min walk) with mortality and adverse cardiovascular outcomes in the elderly. <b><i>Methods:</i></b> Participants in the Cardiovascular Health Study who completed a 6-min walk test were included. We used delta heart rate (difference between postwalk heart rate and resting heart rate) as a measure of chronotropic response and examined its association with (1) all-cause mortality and (2) incident coronary heart disease event, using multivariable Cox regression models. <b><i>Results:</i></b> We included 2,224 participants (mean age 77 ± 4 years; 60% women; 85% white). The average delta heart rate was 26 beats/min. Participants in the lowest tertile of delta heart rate (<20 beats/min) had higher risk-adjusted mortality [hazard ratio (HR) 1.18, 95% confidence interval (CI) 1.00–1.40] and incident coronary heart disease (HR 1.37, 95% CI 1.05–1.78) compared to subjects in the highest tertile (≥30 beats/min), with a significant linear trend across tertiles (p for trend <0.05 for both outcomes). This relationship was not significant after adjustment for distance walked. <b><i>Conclusion:</i></b> Impaired chronotropic response during a 6-min walk test was associated with an increased risk of mortality and incident coronary heart disease among the elderly. This association was attenuated after adjusting for distance walked. 2012-06-20 00:00:00 Coronary heart disease Exercise Heart rate Elderly