10.6084/m9.figshare.5123167.v1
Müller A.
Müller
A.
Möller M.
Möller
M.
Adams L.A.
Adams
L.A.
Warren R.M.
Warren
R.M.
Hoal E.G.
Hoal
E.G.
van Helden P.D.
van Helden P.D.
Supplementary Material for: Comparative Analysis of a Putative Tuberculosis-Susceptibility Gene, <i>MC3R</i>, and Pseudogene Sequences in Cattle, African Buffalo, Hyena, Rhinoceros and Other African Bovids and Ruminants
Karger Publishers
2012
African wildlife
Bovids
Bovine tuberculosis
Gene sequence
Host susceptibility
Melanocortin-3-receptor
Pseudogene
Ruminants
2012-01-25 00:00:00
Dataset
https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Comparative_Analysis_of_a_Putative_Tuberculosis-Susceptibility_Gene_i_MC3R_i_and_Pseudogene_Sequences_in_Cattle_African_Buffalo_Hyena_Rhinoceros_and_Other_African_Bovids_and_Ruminants/5123167
Studies in humans have suggested the possible involvement of melanocortin-3-receptor (MC3R) and other components of the central melanocortin system in host defense against mycobacteria. We report a genomic DNA nucleotide sequence highly homologous to human <i>MC3R</i> in several bovids and non-bovid African wildlife species. Nucleotide sequence analysis indicates that the orthologous genes of cattle and buffalo are highly homologous (89.4 and 90%, respectively) to the human <i>MC3R</i> gene. Sequence results also identified a typical non-functional, duplicated pseudogene, <i>MC3RP</i>, in 7 species from the family Bovidae. No pseudogene was found in animals outside Bovidae. The presence of the pseudogene in tuberculosis-susceptible species could have possible immunomodulatory effects on susceptibility to bovine tuberculosis infection, as well as a considerable influence on energy metabolism and food conversion efficiency.