10.6084/m9.figshare.5123167.v1 Müller A. Müller A. Möller M. Möller M. Adams L.A. Adams L.A. Warren R.M. Warren R.M. Hoal E.G. Hoal E.G. van Helden P.D. van Helden P.D. Supplementary Material for: Comparative Analysis of a Putative Tuberculosis-Susceptibility Gene, <i>MC3R</i>, and Pseudogene Sequences in Cattle, African Buffalo, Hyena, Rhinoceros and Other African Bovids and Ruminants Karger Publishers 2012 African wildlife Bovids Bovine tuberculosis Gene sequence Host susceptibility Melanocortin-3-receptor Pseudogene Ruminants 2012-01-25 00:00:00 Dataset https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Comparative_Analysis_of_a_Putative_Tuberculosis-Susceptibility_Gene_i_MC3R_i_and_Pseudogene_Sequences_in_Cattle_African_Buffalo_Hyena_Rhinoceros_and_Other_African_Bovids_and_Ruminants/5123167 Studies in humans have suggested the possible involvement of melanocortin-3-receptor (MC3R) and other components of the central melanocortin system in host defense against mycobacteria. We report a genomic DNA nucleotide sequence highly homologous to human <i>MC3R</i> in several bovids and non-bovid African wildlife species. Nucleotide sequence analysis indicates that the orthologous genes of cattle and buffalo are highly homologous (89.4 and 90%, respectively) to the human <i>MC3R</i> gene. Sequence results also identified a typical non-functional, duplicated pseudogene, <i>MC3RP</i>, in 7 species from the family Bovidae. No pseudogene was found in animals outside Bovidae. The presence of the pseudogene in tuberculosis-susceptible species could have possible immunomodulatory effects on susceptibility to bovine tuberculosis infection, as well as a considerable influence on energy metabolism and food conversion efficiency.