%0 Generic
%A A.S., Zinkernagel
%A P., Hruz
%A S., Uchiyama
%A von Köckritz-Blickwede M.
%A R.A., Schuepbach
%A T., Hayashi
%A D.A., Carson
%A V., Nizet
%D 2011
%T Supplementary Material for: Importance of Toll-Like Receptor 9 in Host Defense against M1T1 Group A Streptococcus Infections
%U https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Importance_of_Toll-Like_Receptor_9_in_Host_Defense_against_M1T1_Group_A_i_Streptococcus_i_Infections/5122582
%R 10.6084/m9.figshare.5122582.v1
%2 https://ndownloader.figshare.com/files/8707615
%K Innate immunity
%K Toll-like receptor 9
%K Group A Streptococcus
%X Timely recognition and elimination of invasive group A Streptococcus (GAS) by innate immunity is crucial to control infection. The intracellular pattern recognition receptor Toll-like receptor 9 (TLR9) promotes macrophage hypoxia-inducible factor-1α levels, oxidative burst and nitric oxide production in response to GAS. TLR9 contributes to GAS clearance in vivo in both localized cutaneous and systemic infection models.
%I Karger Publishers