%0 Generic %A A.S., Zinkernagel %A P., Hruz %A S., Uchiyama %A von Köckritz-Blickwede M. %A R.A., Schuepbach %A T., Hayashi %A D.A., Carson %A V., Nizet %D 2011 %T Supplementary Material for: Importance of Toll-Like Receptor 9 in Host Defense against M1T1 Group A Streptococcus Infections %U https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Importance_of_Toll-Like_Receptor_9_in_Host_Defense_against_M1T1_Group_A_i_Streptococcus_i_Infections/5122582 %R 10.6084/m9.figshare.5122582.v1 %2 https://ndownloader.figshare.com/files/8707615 %K Innate immunity %K Toll-like receptor 9 %K Group A Streptococcus %X Timely recognition and elimination of invasive group A Streptococcus (GAS) by innate immunity is crucial to control infection. The intracellular pattern recognition receptor Toll-like receptor 9 (TLR9) promotes macrophage hypoxia-inducible factor-1α levels, oxidative burst and nitric oxide production in response to GAS. TLR9 contributes to GAS clearance in vivo in both localized cutaneous and systemic infection models. %I Karger Publishers