TY - DATA T1 - Supplementary Material for: Progesterone Level Predicts Serotonin-1A Receptor Binding in the Male Human Brain PY - 2011/05/21 AU - Lanzenberger R. AU - Mitterhauser M. AU - Kranz G.S. AU - Spindelegger C. AU - Wadsak W. AU - Stein P. AU - Moser U. AU - Savli M. AU - Kletter K. AU - Kasper S. UR - https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Progesterone_Level_Predicts_Serotonin-1A_Receptor_Binding_in_the_Male_Human_Brain/5122477 DO - 10.6084/m9.figshare.5122477.v1 L4 - https://ndownloader.figshare.com/files/8707441 KW - Progesterone KW - Serotonin KW - Positron emission tomography KW - Cortisol N2 - Background: Progesterone (P) is thought to influence mood and affective states. Alterations of the inhibitory serotonin-1A (5-HT1A) receptor distribution are associated with depression and anxiety. This study evaluates the influence of plasma P levels on the 5-HT1A receptor binding in healthy male subjects. Methods: Molecular neuroimaging of the 5-HT1A receptor distribution using positron emission tomography and hormone assays for total plasma P and cortisol were done in a sample of 18 healthy men. Results: Plasma P levels explained up to 65% of the variability in 5-HT1A receptor binding in limbic regions including the amygdala, orbitofrontal cortex and retrosplenial cortex. When controlling for cortisol in the model, there was an expected decline in explained variances of 5-HT1A binding attributed to P. Conclusions: The results of this study provide further support for the effect of P on 5-HT1A receptor expression and raise the possibility that P mediates the vulnerability to mood disorders by affecting the serotonergic system. ER -