TY - DATA T1 - Supplementary Material for: Antiviral Resistance Mutations and Genotype-Associated Amino Acid Substitutions in Treatment-Naïve Hepatitis B Virus-Infected Individuals from the Indian Subcontinent PY - 2011/02/11 AU - Ismail A.M. AU - Samuel P. AU - Eapen C.E. AU - Kannangai R. AU - Abraham P. UR - https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Antiviral_Resistance_Mutations_and_Genotype-Associated_Amino_Acid_Substitutions_in_Treatment-Na_ve_Hepatitis_B_Virus-Infected_Individuals_from_the_Indian_Subcontinent/5121640 DO - 10.6084/m9.figshare.5121640.v1 L4 - https://ndownloader.figshare.com/files/8706253 KW - Antiviral therapy KW - Mutation KW - Drug resistance KW - Genotypes KW - Hepatitis B virus KW - Reverse transcriptase N2 - Background/Aims: Antiviral resistance is a major challenge to the treatment currently available for hepatitis B virus (HBV). In this study, mutations that may affect the antiviral efficacy in treatment-naïve HBV-infected individuals were analyzed. Methods: Ninety-seven treatment-naïve HBV-infected individuals were included in this study. HBV reverse transcriptase (rt) domains were sequenced and nucleotide differences were compared to GenBank wild-type sequences. Furthermore, HBV genotypes, subgenotypes and subtypes were determined by analyzing surface gene sequences. Results: An adefovir-related rtI233V mutation was identified in 4 subjects. The rtS213T lamivudine and entecavir refractory mutant was presented in 3 individuals. Altogether, drug-related, atypical and novel HBVrt amino acid substitutions were seen in 73 positions. The HBV genotypes A, C, D and G were depicted in 15, 21, 60 and 1 individuals, respectively. There were 17 HBVrt amino acid substitutions that are associated with certain genotypes of HBV. Mutations in HBVrt corresponded to established surface gene mutations in 9 patients. Conclusion: This data shows that antiviral-resistant HBV strains do exist in treatment-naïve individuals in this region. Further studies are essential to characterize the role of HBVrt amino acid substitutions in response to anti-HBV therapy. ER -