%0 Generic %A J., Gao %A H., Xu %A C., Weinberg %A X., Huang %A Y., Park %A A., Hollenbeck %A A., Blair %A A., Schatzkin %A L., Burch %A H., Chen %D 2011 %T Supplementary Material for: An Exploratory Study on the CHRNA3-CHRNA5-CHRNB4 Cluster, Smoking, and Parkinson’s Disease %U https://karger.figshare.com/articles/dataset/Supplementary_Material_for_An_Exploratory_Study_on_the_i_CHRNA3-CHRNA5-CHRNB4_i_Cluster_Smoking_and_Parkinson_s_Disease/5121610 %R 10.6084/m9.figshare.5121610.v1 %2 https://ndownloader.figshare.com/files/8706214 %K Parkinson’s disease %K Smoking %K CHRNA3-CHRNA5-CHRNB4 cluster %K Nicotine dependence %X Background: Smokers have a lower risk of Parkinson’s disease (PD). Recent genome-wide association studies (GWAS) have consistently linked several single nucleotide polymorphisms (SNPs) in the CHRNA3-CHRNA5-CHRNB4 cluster on chromosome 15.q25 to smoking behaviors and nicotine dependence. Investigations into these SNPs may help explain the nature and mechanisms of the smoking-PD relationship. Objective: To examine whether the genetic variations that were consistently associated with smoking or nicotine dependence in recent GWAS also predict the risk of PD. Methods: This is a population-based case-control study of 788 physician-diagnosed PD patients and 911 controls, all non-Hispanic Whites. Seven SNPs were selected based on findings from recent GWAS on smoking and nicotine dependence, all from the nicotinic acetylcholine receptor subunits (CHRN) A3-A5-B4. Odds ratios (ORs) and 95% confidence intervals were derived from logistic regression models under the assumption of logit-additive allelic effects. Results: Four SNPs in linkage disequilibrium from the CHRNA3-CHRNA5-CHRNB4 cluster were associated with smoking duration (OR >1.3, p < 0.05). However, none of the SNPs from this cluster was associated with PD risk in the overall analysis or after stratifying on smoking status. Conclusion: This preliminary analysis does not support a relationship between these smoking-related GWAS SNPs and PD. %I Karger Publishers