%0 Generic
%A J., Gao
%A H., Xu
%A C., Weinberg
%A X., Huang
%A Y., Park
%A A., Hollenbeck
%A A., Blair
%A A., Schatzkin
%A L., Burch
%A H., Chen
%D 2011
%T Supplementary Material for: An Exploratory Study on the CHRNA3-CHRNA5-CHRNB4 Cluster, Smoking, and Parkinson’s Disease
%U https://karger.figshare.com/articles/dataset/Supplementary_Material_for_An_Exploratory_Study_on_the_i_CHRNA3-CHRNA5-CHRNB4_i_Cluster_Smoking_and_Parkinson_s_Disease/5121610
%R 10.6084/m9.figshare.5121610.v1
%2 https://ndownloader.figshare.com/files/8706214
%K Parkinson’s disease
%K Smoking
%K CHRNA3-CHRNA5-CHRNB4 cluster
%K Nicotine dependence
%X Background: Smokers have a lower risk of Parkinson’s disease (PD). Recent genome-wide association studies (GWAS) have consistently linked several single nucleotide polymorphisms (SNPs) in the CHRNA3-CHRNA5-CHRNB4 cluster on chromosome 15.q25 to smoking behaviors and nicotine dependence. Investigations into these SNPs may help explain the nature and mechanisms of the smoking-PD relationship. Objective: To examine whether the genetic variations that were consistently associated with smoking or nicotine dependence in recent GWAS also predict the risk of PD. Methods: This is a population-based case-control study of 788 physician-diagnosed PD patients and 911 controls, all non-Hispanic Whites. Seven SNPs were selected based on findings from recent GWAS on smoking and nicotine dependence, all from the nicotinic acetylcholine receptor subunits (CHRN) A3-A5-B4. Odds ratios (ORs) and 95% confidence intervals were derived from logistic regression models under the assumption of logit-additive allelic effects. Results: Four SNPs in linkage disequilibrium from the CHRNA3-CHRNA5-CHRNB4 cluster were associated with smoking duration (OR >1.3, p < 0.05). However, none of the SNPs from this cluster was associated with PD risk in the overall analysis or after stratifying on smoking status. Conclusion: This preliminary analysis does not support a relationship between these smoking-related GWAS SNPs and PD.
%I Karger Publishers