Supplementary Material for: Implantable Defibrillators Improve Survival in End-Stage Renal Disease: Results from a Multi-Center Registry Hiremath S. Punnam S.R. Brar S.S. Goyal S.K. Gardiner J.C. Shah A.J. Thakur R.K. 10.6084/m9.figshare.5121352.v1 https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Implantable_Defibrillators_Improve_Survival_in_End-Stage_Renal_Disease_Results_from_a_Multi-Center_Registry/5121352 <i>Background:</i> Small retrospective analyses suggest that end-stage renal disease (ESRD) patients do not obtain as much of a survival benefit from an implantable cardioverter-defibrillator (ICD) as non-ESRD patients do. We aimed to assess the survival effect of an ICD in ESRD patients with left ventricular dysfunction. <i>Methods:</i> Data from two registries identified ESRD patients with an ICD and ESRD patients with left ventricular dysfunction (defined as ejection fraction <0.35). Cox proportional hazards regression was performed, including certain predefined covariates to assess the effect of an ICD on survival. <i>Results:</i> Overall survival in the full cohort was a median of 4.7 years with 20 deaths in the ICD group and 29 deaths in the no-ICD group. The median survival in the ICD group was 8.0 years and 3.1 years in the no-ICD group. Crude analysis showed a better survival in the ICD group as compared to the no-ICD group (p = 0.016). The multivariable analysis confirmed that the ICD group had significantly less all-cause mortality compared to the no-ICD group (HR: 0.40; 95% CI: 0.19, 0.82; p = 0.013). <i>Conclusion:</i> An ICD is associated with a higher survival in ESRD patients with left ventricular dysfunction. This result merits further study in a larger cohort of patients. 2010-08-16 00:00:00 Hemodialysis Mortality Epidemiology Sudden death Electrophysiology