TY - DATA T1 - Supplementary Material for: Dendritic Spine Alterations in Neocortical Pyramidal Neurons following Postnatal Neuronal Nogo-A Knockdown PY - 2010/10/13 AU - Pradhan A.D. AU - Case A.M. AU - Farrer R.G. AU - Tsai S.Y. AU - Cheatwood J.L. AU - Martin J.L. AU - Kartje G.L. UR - https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Dendritic_Spine_Alterations_in_Neocortical_Pyramidal_Neurons_following_Postnatal_Neuronal_Nogo-A_Knockdown/5121142 DO - 10.6084/m9.figshare.5121142.v1 L4 - https://ndownloader.figshare.com/files/8705563 KW - Cerebral cortex KW - Adeno-associated virus KW - Short hairpin RNA KW - Pyramidal neuron N2 - The myelin-associated protein Nogo-A is a well-known inhibitor of axonal regeneration and compensatory plasticity, yet functions of neuronal Nogo-A are not as clear. The present study examined the effects of decreased levels of neuronal Nogo-A on dendritic spines of developing neocortical neurons. Decreased Nogo-A levels in these neurons resulted in lowered spine density and an increase in filopodial type protrusions. These results suggest a role for neuronal Nogo-A in maintaining a spine phenotype in neocortical pyramidal cells. ER -