10.6084/m9.figshare.5120917.v1
Shen X.
Shen
X.
Shi R.
Shi
R.
Zhang H.
Zhang
H.
Li K.
Li
K.
Zhao Y.
Zhao
Y.
Zhang R.
Zhang
R.
Supplementary Material for: The Toll-Like Receptor 4 D299G and T399I Polymorphisms Are Associated with Crohn’s Disease and Ulcerative Colitis: A Meta-Analysis
Karger Publishers
2010
Toll-like receptor 4
Polymorphism
Crohn’s disease, susceptibility
Ulcerative colitis, susceptibility
Meta-analysis
2010-01-09 00:00:00
Dataset
https://karger.figshare.com/articles/dataset/Supplementary_Material_for_The_Toll-Like_Receptor_4_D299G_and_T399I_Polymorphisms_Are_Associated_with_Crohn_s_Disease_and_Ulcerative_Colitis_A_Meta-Analysis/5120917
<i>Background:</i> Some studies have reported that Toll-like receptor 4 <i>(TLR4)</i> D299G and T399I polymorphisms are associated with increased Crohn’s disease (CD) and ulcerative colitis (UC) risk in the Caucasian population. However, the results have been inconsistent. <i>Methods:</i> A systemic review of the published data (16 studies with 8,387 cases and 7,013 controls for D299G; 8 studies with 3,881 cases and 1,861 controls for T399I) was undertaken and a meta-analysis was performed to test whether <i>TLR4</i> D299G and T399I polymorphisms were associated with CD or UC susceptibility and whether 299Gly carriage was associated with phenotypes of CD patients. <i>Results:</i> The <i>TLR4 </i>299Gly allele showed a significant association with CD and UC in the Caucasian population (OR 1.29, 95% CI 1.08–1.54, and OR 1.28, 95% CI 1.08–1.51, respectively). Similar association was detected between the T399I polymorphism and susceptibility to CD and UC (OR 1.37, 95% CI 1.12–1.68, and OR 1.46, 95% CI 1.13–1.88, respectively). However, no significant association was identified between CD phenotypes and 299Gly carriage. <i>Conclusion:</i> The meta-analysis showed that <i>TLR4</i> D299G and T399I confer a significant risk for developing CD and UC in Caucasians. Additional well-powered studies of the association between <i>TLR4</i> variants and UC are needed.