TY - DATA T1 - Supplementary Material for: DTNBP1, NRG1, DAOA, DAO and GRM3 Polymorphisms and Schizophrenia: An Association Study PY - 2009/05/12 AU - Jönsson E.G. AU - Saetre P. AU - Vares M. AU - Andreou D. AU - Larsson K. AU - Timm S. AU - Rasmussen H.B. AU - Djurovic S. AU - Melle I. AU - Andreassen O.A. UR - https://karger.figshare.com/articles/dataset/Supplementary_Material_for_i_DTNBP1_NRG1_DAOA_i_i_DAO_i_and_i_GRM3_i_Polymorphisms_and_Schizophrenia_An_Association_Study/5120701 DO - 10.6084/m9.figshare.5120701.v1 L4 - https://ndownloader.figshare.com/files/8705002 KW - Dysbindin gene KW - Neuregulin 1 KW - D-amino-acid oxidase gene KW - D-amino-acid oxidase activator KW - Metabotropic glutamate receptor 3 KW - Single-nucleotide polymorphisms KW - Schizophrenia N2 - Background: Several studies of the dystrobrevin-binding protein 1 gene (DTNBP1), neuregulin 1 (NRG1), D-amino-acid oxidase (DAO), DAO activator (DAOA, G72), and metabotropic glutamate receptor 3 (GRM3) genes have suggested an association between variants of these genes and schizophrenia. Methods: In a replication attempt, single-nucleotide polymorphisms of the DTNBP1, NRG1, DAO, DAOA, and GRM3 genes were analyzed in three independent Scandinavian schizophrenia case-control samples. Results: One DTNBP1 and three GRM3 single-nucleotide polymorphisms showed nominal significant associations to the disease. However, after correction for multiple testing, there were no statistically significant allele, genotype or haplotype case-control differences. Conclusions: The present Scandinavian results do not verify previous associations between the analyzed DTNBP1, NRG1, DAO, DAOA, and GRM3 gene polymorphisms and schizophrenia. Additional studies and meta-analyses are warranted to shed further light on these relationships. ER -