%0 Generic
%A R., Cassata
%A A., Iannuzzi
%A P., Parma
%A De Lorenzi L.
%A V., Peretti
%A A., Perucatti
%A L., Iannuzzi
%A Di Meo G.P.
%D 2008
%T Supplementary Material for: Clinical, cytogenetic and molecular evaluation in a dog with bilateral cryptorchidism and hypospadias
%U https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Clinical_cytogenetic_and_molecular_evaluation_in_a_dog_with_bilateral_cryptorchidism_and_hypospadias/5120365
%R 10.6084/m9.figshare.5120365.v1
%2 https://ndownloader.figshare.com/files/8704279
%K Medicine
%X The aim of this study was to estimate prognostic factors in a Dalmatian dog with bilateral cryptorchidism and hypospadias. Cytogenetic and molecular analyses revealed a normal karyotype (2n = 78,XY) and the presence of SRY, INSL3 and RXFP2 genes with a normal DNA sequence for SRY and RXFP2, while the INSL3 sequence differed slightly from the normal one due to a heterozygous nucleotide change involving amino acid 22 of the INSL3 dog precursor protein. Levels of plasmatic testosterone were only 0.01 ng/ml, while FSH and LH serum levels were not detectable. After the human chorionic gonadotropin (hCG) test, the serum testosterone level was 0.01 ng/ml. Therefore, the phenotypic aetiology of this subject can not be well-defined because cryptorchidism and hypospadias were frequent clinical features with high genetic heterogeneity.
%I Karger Publishers