10.1371/journal.pone.0179936.g004 Zheng Zhao Zheng Zhao Lei Xie Lei Xie Philip E. Bourne Philip E. Bourne Two conserved interatomic interactions between MEK and the ligand. Public Library of Science 2017 MEK type-III kinase inhibitors type-III kinase inhibitors helix-folding activation loop Type-III kinase inhibitors allosteric binding sites type-III inhibitors MEK-targeted type-III inhibitors binding mode kinome Protein kinases allosteric kinase inhibitors MEK type-III inhibitors hallmark allosteric binding site 2017-06-19 17:42:42 Figure https://plos.figshare.com/articles/figure/Two_conserved_interatomic_interactions_between_MEK_and_the_ligand_/5119534 <p>(a) Interatomic distances for every conformation from the MD trajectory; (b) The probability distribution of interatomic distances.</p>