10.1371/journal.pone.0179327.g002
Rahul Sampath
Rahul
Sampath
Nathan W. Cummins
Nathan
W. Cummins
Sekar Natesampillai
Sekar
Natesampillai
Gary D. Bren
Gary
D. Bren
Thomas D. Chung
Thomas D.
Chung
Jason Baker
Jason
Baker
Keith Henry
Keith
Henry
Amélie Pagliuzza
Amélie
Pagliuzza
Andrew D. Badley
Andrew
D. Badley
Procaspase 8 inducing drugs in acute <i>in vitro</i> HIV infection model.
Public Library of Science
2017
vivo patient cells HIV
CD 4 T cells
cytotoxic protein Casp 8p
procaspase 8 levels
cell-associated HIV DNA levels
HIV reactivation
increase Casp 8p
9 drugs
Primary CD 4 T cells
cell-associated HIV DNA
HIV protease cleaving procaspase 8.
procaspase 8 expression
Casp 8p levels
HIV IIIb infection model
HIV DNA levels
Screening 1277 FDA
cell death
reactivating cells
2017-06-19 17:37:15
Figure
https://plos.figshare.com/articles/figure/Procaspase_8_inducing_drugs_in_acute_i_in_vitro_i_HIV_infection_model_/5119003
<p><b>A)</b> Primary uninfected CD4 cells from 3 donors were infected with HIV IIIB and then incubated with procaspase 8 inducing drugs for 48hours with RAL and TDF. ATP, HIV DNA by qPCR <b>(B)</b>, and supernatant P24 <b>(D)</b> were assessed. <b>C)</b> The degree of procaspase 8 expression induction by ELISA was compared between drugs which reduced HIV DNA or did not reduce HIV DNA in panel (B). Depicted are means (SD). E) Pearson correlation coefficient between the change in cell associated HIV DNA and change in supernatant p24 was assessed.</p>