%0 Generic %A Dwivedi, Vikas %A Kumar, Ravi %A Sharma, Kavita %A Sridhar, Balasubramanian %A Reddy, Maddi Sridhar %D 2017 %T Copper-Promoted Regioselective Intermolecular Diamination of Ynamides: Synthesis of Imidazo[1,2‑a]pyridines %U https://acs.figshare.com/articles/dataset/Copper-Promoted_Regioselective_Intermolecular_Diamination_of_Ynamides_Synthesis_of_Imidazo_1_2_i_a_i_pyridines/5117683 %R 10.1021/acsomega.7b00426.s002 %2 https://ndownloader.figshare.com/files/8698681 %K heterosubstitution %K 3. %K electron bias %K oxazolidinonyl %K Ynamide %K heterosubstituted %K regioselective %K diamination %K ether %K access %K ynamide %K Imidazo %K Cu %K Synthesi %K electron-rich %K Copper-Promoted Regioselective Intermolecular Diamination %K imidazo %K regioisomer %K alkyne %K 2- aminopyridines %K 3- %X A facile access to 3-heterosubstituted (3-oxazolidinonyl/indolyl/phenoxy) imidazo­[1,2-a]­pyridines from readily available 2-aminopyridines and electron-rich (internally activated) alkynes like ynamides/ynamines/ynol ethers is achieved via Cu­(OTf)2-mediated intermolecular diamination under aerobic conditions. The reaction is highly regioselective, owing to internal electron bias, and thus led to a single regioisomer with heterosubstitution at C3. %I ACS Publications