%0 Generic
%A Dwivedi, Vikas
%A Kumar, Ravi
%A Sharma, Kavita
%A Sridhar, Balasubramanian
%A Reddy, Maddi Sridhar
%D 2017
%T Copper-Promoted Regioselective
Intermolecular Diamination of Ynamides:
Synthesis of Imidazo[1,2‑a]pyridines
%U https://acs.figshare.com/articles/dataset/Copper-Promoted_Regioselective_Intermolecular_Diamination_of_Ynamides_Synthesis_of_Imidazo_1_2_i_a_i_pyridines/5117683
%R 10.1021/acsomega.7b00426.s002
%2 https://ndownloader.figshare.com/files/8698681
%K heterosubstitution
%K 3.
%K electron bias
%K oxazolidinonyl
%K Ynamide
%K heterosubstituted
%K regioselective
%K diamination
%K ether
%K access
%K ynamide
%K Imidazo
%K Cu
%K Synthesi
%K electron-rich
%K Copper-Promoted Regioselective Intermolecular Diamination
%K imidazo
%K regioisomer
%K alkyne
%K 2- aminopyridines
%K 3-
%X A facile access to 3-heterosubstituted
(3-oxazolidinonyl/indolyl/phenoxy)
imidazo[1,2-a]pyridines from readily available 2-aminopyridines
and electron-rich (internally activated) alkynes like ynamides/ynamines/ynol
ethers is achieved via Cu(OTf)2-mediated intermolecular
diamination under aerobic conditions. The reaction is highly regioselective,
owing to internal electron bias, and thus led to a single regioisomer
with heterosubstitution at C3.
%I ACS Publications