Additional file 1: Figure S1. of Biomarker correlation network in colorectal carcinoma by tumor anatomic location NishiharaReiko GlassKimberly MimaKosuke HamadaTsuyoshi NowakJonathan QianZhi KraftPeter GiovannucciEdward FuchsCharles ChanAndrew QuackenbushJohn OginoShuji OnnelaJukka-Pekka 2017 The biomarker network in colorectal cancer. A node represents a molecular feature, and an edge specifies the Spearman correlation between two markers with a significance level of 3.5 × 10−5 (0.05/1431, based on the Bonferroni correction). The red line indicates a positive correlation, and the blue line indicates a negative correlation. The line width is proportional to a correlation coefficient. CDKN2A (IHC), protein expression of CDKN2A; CDKN2A, methylation level of CDKN2A; LINE-1, methylation level of long interspersed nucleotide element 1; MSI, microsatellite instability; TIL, lymphocytes on top of neoplastic epithelial cells. (TIFF 344 KB)