10.6084/m9.figshare.c.3805510_D1.v1 Reiko Nishihara Reiko Nishihara Kimberly Glass Kimberly Glass Kosuke Mima Kosuke Mima Tsuyoshi Hamada Tsuyoshi Hamada Jonathan Nowak Jonathan Nowak Zhi Qian Zhi Qian Peter Kraft Peter Kraft Edward Giovannucci Edward Giovannucci Charles Fuchs Charles Fuchs Andrew Chan Andrew Chan John Quackenbush John Quackenbush Shuji Ogino Shuji Ogino Jukka-Pekka Onnela Jukka-Pekka Onnela Additional file 1: Figure S1. of Biomarker correlation network in colorectal carcinoma by tumor anatomic location Springer Nature 2017 biomarker network colorectal carcinoma MSI Bonferroni correction neoplastic epithelial cells correlation coefficient microsatellite instability line width TIFF 344 KB Biomarker correlation network significance level colorectal cancer TIL CDKN 2A IHC CDKN 2A CDKN 2A methylation level Spearman correlation 2017-06-17 05:00:00 Figure https://springernature.figshare.com/articles/figure/Additional_file_1_Figure_S1_of_Biomarker_correlation_network_in_colorectal_carcinoma_by_tumor_anatomic_location/5116996 The biomarker network in colorectal cancer. A node represents a molecular feature, and an edge specifies the Spearman correlation between two markers with a significance level of 3.5 × 10−5 (0.05/1431, based on the Bonferroni correction). The red line indicates a positive correlation, and the blue line indicates a negative correlation. The line width is proportional to a correlation coefficient. CDKN2A (IHC), protein expression of CDKN2A; CDKN2A, methylation level of CDKN2A; LINE-1, methylation level of long interspersed nucleotide element 1; MSI, microsatellite instability; TIL, lymphocytes on top of neoplastic epithelial cells. (TIFF 344 KB)