10.1021/acs.orglett.7b01371.s001 Sandhya Badrinarayanan Sandhya Badrinarayanan Christopher J. Squire Christopher J. Squire Jonathan Sperry Jonathan Sperry Margaret A. Brimble Margaret A. Brimble Bioinspired Total Synthesis and Stereochemical Revision of the Fungal Metabolite Pestalospirane B American Chemical Society 2017 dichroism ECD Stereochemical Revision X-ray analysis Fungal Metabolite Pestalospirane B 12 S stereochemistry pestalospirane B synthesis dimerization Bioinspired 3 S bioinspired 12 R enantiomer 3 R tandem product pestalospirane B Synthesi Electronic 2017-06-16 18:18:42 Journal contribution https://acs.figshare.com/articles/journal_contribution/Bioinspired_Total_Synthesis_and_Stereochemical_Revision_of_the_Fungal_Metabolite_Pestalospirane_B/5116198 The total synthesis of both enantiomers of pestalospirane B, <b>2</b>, has been achieved using a bioinspired tandem dimerization–spiroketalization reaction. Electronic circular dichroism (ECD) and X-ray analysis were used to revise the absolute stereochemistry of the natural product pestalospirane B from 3<i>S</i>, 3′<i>S</i>, 12<i>R</i>, 12′<i>R</i> to its enantiomer 3<i>R</i>, 3′<i>R</i>, 12<i>S</i>, 12′<i>S</i>.