Supplementary Material for: Preoperative C-Reactive Protein Values as a Potential Component in Outcome Prediction Models of Metastasized Renal Cell Carcinoma Patients Receiving Cytoreductive Nephrectomy
Kalogirou C.
Mulfinger P.
Sokolakis I.
Krebs M.
Kübler H.
Riedmiller H.
Vergho D.
10.6084/m9.figshare.5114041.v1
https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Preoperative_C-Reactive_Protein_Values_as_a_Potential_Component_in_Outcome_Prediction_Models_of_Metastasized_Renal_Cell_Carcinoma_Patients_Receiving_Cytoreductive_Nephrectomy/5114041
<p><b><i>Purpose:</i></b> To validate preoperative C-reactive protein
(CRP) levels as a prognostic marker for survival in a metastasized renal
cell carcinoma (mRCC) patient cohort receiving cytoreductive
nephrectomy (CN). <b><i>Patients and Methods:</i></b> By chart review,
146 mRCC patients receiving CN at our tertiary referral centre from 1997
to 2015 were identified retrospectively. All relevant
clinicopathological features including laboratory parameters were
collected and correlated to overall survival, progression-free survival
and cancer-specific survival (CSS). The mean follow-up was 23 months
(range 1-168 months). <b><i>Results:</i></b> Besides the already
established scoring systems like the MSKCC criteria, an elevated
preoperative CRP level (≥0.5 mg/dL) was an independent predictor of CSS
in our study group including the chosen postoperative adjuvant therapies
(TKI vs. immunotherapy vs. others). With regard to morbidity, patients
with a good performance status, small tumour size and adequate renal
function/haematopoiesis experienced less complication rates, thereby
profiting more from CN. <b><i>Conclusions:</i></b> Our data provide
indication that preoperative CRP levels should be implemented in
nomograms regarding the outcome prediction in mRCC to identify
candidates likely to profit from CN.</p>
2017-06-16 10:44:27
Cytoreductive nephrectomy
C-reactive protein
Renal cell carcinoma
Metastasized renal cell carcinoma